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Br J Obstet Gynaecol. 1987 Dec;94(12):1199-204.

Effect of nomegestrol acetate, a new 19-nor-progesterone derivative, on pituitary-ovarian function in women.

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1
Clinical Department, Les Mercuriales Tour-Est, Bagnolet, France.

Abstract

After two control cycles, 13 normally menstruating women were treated from day 5 to 25 of the third consecutive cycle with nomegestrol acetate (NOM Ac) 1.25, 2.5 or 5 mg once a day. Plasma oestradiol, FSH and LH concentrations were assayed daily from day 5 to day 25 and plasma progesterone concentrations from day 12 to day 25. Ovulation was inhibited in every woman; LH and progesterone levels were uniformly depressed. With 5 and 2.5 mg/day, plasma oestradiol remained low with high FSH values. With 1.25 mg/day, oestradiol concentrations reached levels similar to those achieved during the control follicular phase, with a concomitant decrease in FSH secretion. These results show an hypothalamic-pituitary effect and suggest an ovarian action, both responsible for a potentially useful contraceptive property.

[Indexed for MEDLINE]

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