Format

Send to

Choose Destination
Eur Radiol. 2019 Jun 21. doi: 10.1007/s00330-019-06296-4. [Epub ahead of print]

Estimation of the radiation dose in pregnancy: an automated patient-specific model using convolutional neural networks.

Xie T1, Zaidi H2,3,4,5.

Author information

1
Division of Nuclear Medicine and Molecular Imaging, Geneva University Hospital, CH-1211, Geneva 4, Switzerland.
2
Division of Nuclear Medicine and Molecular Imaging, Geneva University Hospital, CH-1211, Geneva 4, Switzerland. habib.zaidi@hcuge.ch.
3
Geneva University Neurocenter, Geneva University, CH-1205, Geneva, Switzerland. habib.zaidi@hcuge.ch.
4
Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, 9700 RB, Groningen, Netherlands. habib.zaidi@hcuge.ch.
5
Department of Nuclear Medicine, University of Southern Denmark, 500, Odense, Denmark. habib.zaidi@hcuge.ch.

Abstract

OBJECTIVES:

The conceptus dose during diagnostic imaging procedures for pregnant patients raises health concerns owing to the high radiosensitivity of the developing embryo/fetus. The aim of this work is to develop a methodology for automated construction of patient-specific computational phantoms based on actual patient CT images to enable accurate estimation of conceptus dose.

METHODS:

We developed a 3D deep convolutional network algorithm for automated segmentation of CT images to build realistic computational phantoms. The neural network architecture consists of analysis and synthesis paths with four resolution levels each, trained on manually labeled CT scans of six identified anatomical structures. Thirty-two CT exams were augmented to 128 datasets and randomly split into 80%/20% for training/testing. The absorbed doses for six segmented organs/tissues from abdominal CT scans were estimated using Monte Carlo calculations. The resulting radiation doses were then compared between the computational models generated using automated segmentation and manual segmentation, serving as reference.

RESULTS:

The Dice similarity coefficient for identified internal organs between manual segmentation and automated segmentation results varies from 0.92 to 0.98 while the mean Hausdorff distance for the uterus is 16.1 mm. The mean absorbed dose for the uterus is 2.9 mGy whereas the mean organ dose differences between manual and automated segmentation techniques are 0.07%, - 0.45%, - 1.55%, - 0.48%, - 0.12%, and 0.28% for the kidney, liver, lung, skeleton, uterus, and total body, respectively.

CONCLUSION:

The proposed methodology allows automated construction of realistic computational models that can be exploited to estimate patient-specific organ radiation doses from radiological imaging procedures.

KEY POINTS:

• The conceptus dose during diagnostic radiology and nuclear medicine imaging procedures for pregnant patients raises health concerns owing to the high radiosensitivity of the developing embryo/fetus. • The proposed methodology allows automated construction of realistic computational models that can be exploited to estimate patient-specific organ radiation doses from radiological imaging procedures. • The dosimetric results can be used for the risk-benefit analysis of radiation hazards to conceptus from diagnostic imaging procedures, thus guiding the decision-making process.

KEYWORDS:

Multidetector-row computed tomography; Patient-specific computational modeling; Radiation dosimetry; Radiologic phantoms

PMID:
31227881
DOI:
10.1007/s00330-019-06296-4

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center