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Nat Commun. 2019 Jun 21;10(1):2752. doi: 10.1038/s41467-019-10711-1.

The role of PS 18:0/18:1 in membrane function.

Author information

1
Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Ullernchausséen 70, 0379, Oslo, Norway. torsko@rr-research.no.
2
Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Ullernchausséen 70, 0379, Oslo, Norway.
3
Department of Biosciences, University of Oslo, 0316 Oslo, Norway.

Abstract

Various studies have demonstrated that the two leaflets of cellular membranes interact, potentially through so-called interdigitation between the fatty acyl groups. While the molecular mechanism underlying interleaflet coupling remains to be fully understood, recent results suggest interactions between the very-long-chain sphingolipids in the outer leaflet, and phosphatidylserine PS18:0/18:1 in the inner leaflet, and an important role for cholesterol for these interactions. Here we review the evidence that cross-linking of sphingolipids may result in clustering of phosphatidylserine and transfer of signals to the cytosol. Although much remains to be uncovered, the molecular properties and abundance of PS 18:0/18:1 suggest a unique role for this lipid.

PMID:
31227693
PMCID:
PMC6588574
DOI:
10.1038/s41467-019-10711-1
[Indexed for MEDLINE]
Free PMC Article

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