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Fertil Steril. 2019 Sep;112(3):520-526.e1. doi: 10.1016/j.fertnstert.2019.04.023. Epub 2019 Jun 18.

Clinical pregnancy (CP) and live birth (LB) increase significantly with each additional fertilized oocyte up to nine, and CP and LB decline after that: an analysis of 15,803 first fresh in vitro fertilization cycles from the Society for Assisted Reproductive Technology registry.

Author information

1
Duke Fertility Center, Duke University, Durham, North Carolina.
2
Department of Biostatistics and Bioinformatics, Duke University, Durham, North Carolina.
3
Duke Fertility Center, Duke University, Durham, North Carolina. Electronic address: muashersj@gmail.com.

Abstract

OBJECTIVE:

To study the association between the total number of fertilized oocytes available and pregnancy outcomes in first fresh IVF cycles with a single blastocyst transfer.

DESIGN:

Retrospective cohort study.

SETTING:

Not applicable.

PATIENT(S):

A total of 15,803 patients from SART reporting fertility clinics.

INTERVENTION(S):

None.

MAIN OUTCOME MEASURE(S):

Primary outcomes were clinical pregnancy (CP), live birth (LB), and miscarriage rates. Logistic regression was used to investigate the association between the number of fertilized eggs and each outcome.

RESULT(S):

The median number of total oocytes was 15, and the median number of fertilized oocytes was nine. The odds of a clinical pregnancy were 8% higher for each additional fertilized oocyte up to nine (odds ratio [OR] 1.08; 95% confidence interval [CI] 1.07-1.10) and declined by 9% for every additional fertilized oocyte after nine (OR 0.91; 95% CI 0.89-0.94). Similarly, the odds of an LB was 8% higher for every additional fertilized oocyte up to none (OR 1.08; 95% CI 1.06-1.10) and declined by 8% for every additional fertilized oocyte over nine (OR 0.92; 95% CI 0.90-0.94).

CONCLUSION(S):

Odds of pregnancy outcomes (CP, LB) increase significantly with every additional fertilized oocyte up to nine, and CP and LB decline after that in first fresh autologous cycles with a single blastocyst transfer.

KEYWORDS:

Clinical pregnancy; IVF; fertilized oocyte; live birth

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