Send to

Choose Destination
Psychiatry Res. 2019 Aug;278:228-234. doi: 10.1016/j.psychres.2019.06.007. Epub 2019 Jun 6.

Comorbidity profile of mental disorders among adolescents: A latent class analysis.

Author information

Department of Psychology, Whitelands College, University of Roehampton, Holybourne Avenue, London SW15 4JD, UK. Electronic address:
Centre for Biomedical Research in Mental Health (CIBERSAM), Universidad Autónoma de Madrid, Spain.


The aim of this study was to identify the number of comorbidity profiles among adolescents. Sociodemographic factors associated with the comorbidity profiles were also examined. Latent class analysis was conducted using data from the National Comorbidity Survey Adolescent Supplement (NCS-A), a representative sample of adolescents (N = 10,123) in the United States. Latent classes were derived from 26 lifetime mental disorders which were assessed using the World Health Organization Composite International Diagnostic Instrument (CIDI). A three-class solution provided the best fit for the data, with classes labelled as comorbid emotional disorders (Class I), comorbid behavioural disorders (Class II), and normative (Class III). Class I (15.62% of the participants) included adolescents with a high probability of having anxiety, depressive, and intermittent explosive disorder. Class II (6.97%) was characterised by adolescents with a high probability of having substance use, behavioural disorders, and major depression. Class III (77.41%) was characterised by adolescents with a low probability of having any mental disorders. Characterising comorbid profile of mental disorders using person-based approach yields a higher-order classification that could have important clinical implications.


Adolescents; Comorbidity; Latent class analysis; Psychopathology

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center