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Mol Cell. 2019 Jun 20;74(6):1105-1107. doi: 10.1016/j.molcel.2019.06.004.

Put the Pedal to the METTL1: Adding Internal m7G Increases mRNA Translation Efficiency and Augments miRNA Processing.

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1
Division of Newborn Medicine, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA.
2
Division of Newborn Medicine, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA. Electronic address: eric.greer@childrens.harvard.edu.

Abstract

Complementary papers by Zhang, Liu, and colleagues (Zhang et al., 2019) and Pandolfini, Barbieri, and colleagues (Pandolfini et al., 2019) develop new sequencing techniques that reveal that METTL1 N7-methylates internal guanosines in mRNAs and miRNAs to increase translation efficiency and miRNA processing, respectively.

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