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Curr Gene Ther. 2019 Jun 21. doi: 10.2174/1566523219666190621111604. [Epub ahead of print]

High Mobility Group Box 1: An Immune-regulatory Protein

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Department of Intensive Care Medicine, Hefei NO.2 People Hospital, Hefei 230000. China.
Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou 215000. China.
Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai 200032. China.
Department of Nursing, General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032. China.


High mobility group box 1 (HMGB1), a highly conserved protein, presents in almost all somatic cells and is necessary for transcription regulation during cell development. Recent studies indicate that HMGB1 is important for inflammation, tissue regeneration and cancer, especially the balance between autophagy and apoptosis. HMGB1 shows a challenge that can be used for therapeutic improvement while preventing its pathological role. Here, we pay attention to the immuno-regulatory effect of HMGB1.


HMGB1; apoptosis; autophagy; cancer; inflammation; tissue regeneration

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