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Adv Mater. 2019 Jun 20:e1900795. doi: 10.1002/adma.201900795. [Epub ahead of print]

Engineering Biomimetic Platesomes for pH-Responsive Drug Delivery and Enhanced Antitumor Activity.

Liu G1,2,3, Zhao X1, Zhang Y1,4, Xu J1,3, Xu J1,3, Li Y1, Min H1, Shi J1, Zhao Y1,4, Wei J2, Wang J1,4, Nie G1,4.

Author information

1
CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190, China.
2
College of Pharmaceutical Science, Jilin University, Changchun, 130021, China.
3
University of Chinese Academy of Sciences, Beijing, 100049, China.
4
Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing, 100049, China.

Abstract

Biomimetic camouflage, i.e., using natural cell membranes for drug delivery, has demonstrated advantages over synthetic materials in both pharmacokinetics and biocompatibility, and so represents a promising solution for the development of safe nanomedicine. However, only limited efforts have been dedicated to engineering such camouflage to endow it with optimized or additional properties, in particular properties critical to a "smart" drug delivery system, such as stimuli-responsive drug release. A pH-responsive biomimetic "platesome" for specific drug delivery to tumors and tumor-triggered drug release is described. This platesome nanovehicle is constructed by merging platelet membranes with functionalized synthetic liposomes and exhibits enhanced tumor affinity, due to its platelet membrane-based camouflage, and selectively releases its cargo in response to the acidic microenvironment of lysosomal compartments. In mouse cancer models, it shows significantly better antitumor efficacy than nanoformulations based on a platesome without pH responsiveness or those based on traditional pH-sensitive liposomes. A convenient way to incorporate stimuli-responsive features into biomimetic nanoparticles is described, demonstrating the potential of engineered cell membranes as biomimetic camouflages for a new generation of biocompatible and efficient nanocarriers.

KEYWORDS:

biomimetic platesomes; drug release; targeted drug delivery

PMID:
31222856
DOI:
10.1002/adma.201900795

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