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Sci Rep. 2019 Jun 20;9(1):8885. doi: 10.1038/s41598-019-45230-y.

Ultrasonographic and elastographic biometry in adult major salivary glands: a preliminary case-control report.

Author information

1
Graduate Institute of Basic Medical Science, College of Medicine, China Medical University, Taichung, Taiwan.
2
Department of Otolaryngology, Far Eastern Memorial Hospital, New Taipei City, Taiwan.
3
Genomics Research Center, Academia Sinica, Taipei, Taiwan.
4
Department of Radiation Oncology, Far Eastern Memorial Hospital, New Taipei City, Taiwan.
5
Department of Otolaryngology, Far Eastern Memorial Hospital, New Taipei City, Taiwan. deniro@mail2000.com.tw.
6
Department of Electrical Engineering, Yuan Ze University, Taoyuan, Taiwan. deniro@mail2000.com.tw.
7
Department of Clinical Engineering, Far Eastern Memorial Hospital, New Taipei City, Taiwan. deniro@mail2000.com.tw.

Abstract

Specifications about the size and stiffness of healthy salivary glands with ultrasound (US) are not available for Asian people. Using a Toshiba Apolio 500 US platform, we determined the size (including anterior-posterior median length, median paramandibular depth dimension, and cranio-caudal height) and hardness of 100 healthy submandibular and parotid glands in volunteers without a history of disease affecting the salivary glands or post-radiation, and compared the dimensions to those of 36 parotid glands and 37 submandibular glands in post-irradiated patients. The dimensions of the parotid and submandibular glands were significantly correlated with body weight. However, the dimension of the parotid glands was not significantly correlated with that of patients with prior radiation; the shear wave velocity (SWV) significantly increased (1.99 m/s versus 2.43 m/s, p-value < 0.01). The dimension of the submandibular glands was significantly correlated with prior radiation, where the SWV also significantly increased (2.32 m/s versus 2.50 m/s, p-values < 0.01). We find that US is a useful tool for assessment of the reference dimensions and hardness of major salivary glands that may be altered by irradiation.

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