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Science. 2019 Jun 21;364(6446). pii: eaav6335. doi: 10.1126/science.aav6335.

Genetic basis of ruminant headgear and rapid antler regeneration.

Author information

1
Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China.
2
Center for Ecological and Environmental Sciences, Northwestern Polytechnical University, Xi'an 710072, China.
3
Department of Special Animal Nutrition and Feed Science, Institute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun 130112, China.
4
Section for Computational and RNA Biology, Department of Biology, University of Copenhagen, DK-2100 Copenhagen, Denmark.
5
Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Chinese Academy of Sciences, Kunming Institute of Zoology, Kunming, Yunnan 650223, China.
6
Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming 650223, China.
7
Institute of Animal Science (IAS), Chinese Academy of Agricultural Sciences (CAAS), Beijing 100193, China.
8
Center of Special Environmental Biomechanics and Biomedical Engineering, School of Life Sciences, Northwestern Polytechnical University, Xi'an 710072, China.
9
Sichuan Institute of Musk Deer Breeding, Sichuan 610000, China.
10
College of Life Sciences, Shihezi University, Shihezi, Xinjiang 832003, China.
11
The Key Laboratory of Animal Biotechnology of Xinjiang, Xinjiang Academy of Animal Science, Xinjiang, Urumqi 830026, China.
12
Recombinetics, Inc., St. Paul, MN 55104, USA.
13
China National GeneBank, BGI-Shenzhen, Shenzhen 518083, China.
14
State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China.
15
Section for Ecology and Evolution, Department of Biology, University of Copenhagen, DK-2100 Copenhagen, Denmark.
16
Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China. qiuqiang@lzu.edu.cn wwang@mail.kiz.ac.cn yu.jiang@nwafu.edu.cn.
17
Center for Ecological and Environmental Sciences, Northwestern Polytechnical University, Xi'an 710072, China. qiuqiang@lzu.edu.cn wwang@mail.kiz.ac.cn yu.jiang@nwafu.edu.cn.

Abstract

Ruminants are the only extant mammalian group possessing bony (osseous) headgear. We obtained 221 transcriptomes from bovids and cervids and sequenced three genomes representing the only two pecoran lineages that convergently lack headgear. Comparative analyses reveal that bovid horns and cervid antlers share similar gene expression profiles and a common cellular basis developed from neural crest stem cells. The rapid regenerative properties of antler tissue involve exploitation of oncogenetic pathways, and at the same time some tumor suppressor genes are under strong selection in deer. These results provide insights into the evolutionary origin of ruminant headgear as well as mammalian organ regeneration and oncogenesis.

PMID:
31221830
DOI:
10.1126/science.aav6335

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