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PLoS One. 2019 Jun 20;14(6):e0218543. doi: 10.1371/journal.pone.0218543. eCollection 2019.

Anti-obesity effects of Spirulina platensis protein hydrolysate by modulating brain-liver axis in high-fat diet fed mice.

Author information

1
College of Food Science and Engineering, South China University of Technology, Guangzhou, China.
2
Guangzhou Institute for Food and Drug Control, Guangzhou, China.
3
Zhongci Health Care Products Technology Development Co. Ltd, Guangzhou, China.
4
Guangzhou Honsea Industry Co. Ltd, Guangzhou, China.

Abstract

Spirulina platensis is a blue-green algae with potential anti-obesity effects. In this study, the anti-obesity effects of whole Spirulina platensis (WSP), Spirulina platensis protein (SPP) and Spirulina platensis protein hydrolysate (SPPH) were compared in high-fat diet fed mice, and the potential acting mechanism of SPPH was also investigated. Totally, SPPH exhibited good anti-obesity effects (reducing 39.8%±9.7% of body weight), lowering 23.8%±1.6% of serum glucose, decreasing 20.8%±1.4% of total cholesterol, while positive drug Simvastatin had the corresponding values: 8.3%±4.6%, 24.8%±1.9% and -2.1%±0.2%, respectively. Subsequently, PCR array was used to conduct gene expression analysis in brain and liver tissues of SPPH-treated mice, which displayed distinctly different expression pattern. The most markedly changed genes included: Acadm (-34.7 fold), Gcg (2.5 fold), Adra2b (2 fold) and Ghsr (2 fold) in brain; Retn (39 fold), Fabp4 (15.5 fold), Ppard (6 fold) and Slc27a1 (5.4 fold) in liver. Further network analysis demonstrated that the significantly expressed genes in brain and liver tissues were mapped into an interacting network, suggesting a modulatory effect on brain-liver axis, major pathways were involved in the axis: PPAR, adipocytokine, AMPK, non-alcoholic fatty liver disease and MAPK. This study showed that Spirulina platensis protein hydrolysate possessed anti-obesity effect in mice.

Conflict of interest statement

The commercial affiliations of Zhongci Health Care Products Technology Development Co. Ltd, Guangzhou, China and Guangzhou Honsea Industry Co. Ltd, Guangzhou, China do not alter our adherence to PLOS ONE policies on sharing data and materials.

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