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Int J Obes (Lond). 2019 Jun 19. doi: 10.1038/s41366-019-0401-5. [Epub ahead of print]

High sleep variability predicts a blunted weight loss response and short sleep duration a reduced decrease in waist circumference in the PREDIMED-Plus Trial.

Author information

1
Departament de Bioquímica i Biotecnologia, Unitat de Nutrició, Universitat Rovira i Virgili, Reus, Spain.
2
Institut d' Investigació Pere Virgili (IISPV), Reus, Spain.
3
Consocio CIBER, M.P. Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain.
4
University Hospital of Sant Joan de Reus, Nutrition Unit, Reus, Spain.
5
Department of Preventive Medicine and Public Health, University of Navarra, Navarra Institute for Health Research (IdiSNA), Pamplona, Spain.
6
Department of Preventive Medicine, University of Valencia, Valencia, Spain.
7
Cardiovascular Risk and Nutrition Research Group, Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain.
8
Nutritional Epidemiology Unit, University of Miguel Hernandez, Isabial-Fisabio, Alicante, Spain.
9
Consorcio CIBER, M.P. Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain.
10
Instituto de Investigación Sanitaria Illes Balears (IdISPa), University Hospital of Son Espases, Palma de Mallorca, Spain.
11
Department of Nutrition, Food Sciences, and Physiology, Center for Nutrition Research, University of Navarra, Pamplona, Spain.
12
Madrid Institute for Advanced Studies (IMDEA) Food Institute, Madrid, Spain.
13
Department of Nursing, School of Health Sciences, University of Malaga-IBIMA, Malaga, Spain.
14
Lipids and Atherosclerosis Unit, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Cordoba, Spain.
15
Department of Internal Medicine, Hospital Clınic, Institut d'Investigacions Biomediques August Pi Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain.
16
Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain.
17
IBS.GRANADA Instituto de Investigación Biosanitaria de Granada, Granada, Spain.
18
Department of Cardiology, University Hospital Araba, Vitoria, Spain.
19
Research Group on Community Nutrition and Oxidative Stress, University of the Balearic Islands, Palma de Mallorca, Spain.
20
Department of Endocrinology and Nutrition, Virgen de la Victoria Hospital, University of Malaga-Institute of Biomedical Research in Malaga (IBIMA), Málaga, Spain.
21
Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria & Centro Hospitalario Universitario Insular Materno Infantil (CHUIMI), Canarian Health Service, Las Palmas de Gran Canaria, Spain.
22
Research Group on Gene-Environment Interactions and Health, University of Leon, Leon, Spain.
23
Biomedicine Institute (IBIOMED), University of Leon, Leon, Spain.
24
Department of Family Medicine, Research Unit, Distrito Sanitario Atención Primaria Sevilla, Sevilla, Spain.
25
Department of Endocrinology and Nutrition, University Hospital Fundación Jimenez Díaz, Madrid, Spain.
26
Lipid Unit, Department of Internal Medicine, Bellvitge Biomedical Research Institute (IDIBELL)-Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain.
27
Endocrinology and Nutrition Department, Hospital Clinic Universitari, Barcelona, Spain.
28
Institut d'Investigacions Biomediques August Pi Sunyer (IDIBAPS), Barcelona, Spain.
29
Consorcio CIBER, M.P. Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain.
30
Emergency Department, Complejo Hospitalario de Navarra, Servicio Navarro de Salud - Osasunbidea, Pamplona, Spain.
31
Department of Health Sciences, University of Jaen, Jaen, Spain.
32
Lipid Clinic, Endocrinology and Nutrition Service, Institut d'Investigacions Biomediques August Pi Sunyer (IDIBAPS), Hospital Clinic, University of Barcelona, Barcelona, Spain.
33
Departament de Bioquímica i Biotecnologia, Unitat de Nutrició, Universitat Rovira i Virgili, Reus, Spain. jordi.salas@urv.cat.
34
Institut d' Investigació Pere Virgili (IISPV), Reus, Spain. jordi.salas@urv.cat.
35
Consocio CIBER, M.P. Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain. jordi.salas@urv.cat.
36
University Hospital of Sant Joan de Reus, Nutrition Unit, Reus, Spain. jordi.salas@urv.cat.

Abstract

BACKGROUND:

Whether short sleep duration or high sleep variability may predict less weight loss and reduction in measures of adiposity in response to lifestyle interventions is unknown. The aim of this study was to compare the 12-month changes in weight and adiposity measures between those participants with short or adequate sleep duration and those with low or high sleep variability (intra-subject standard deviation of the sleep duration) in PREvención con DIeta MEDiterránea (PREDIMED)-Plus, a primary prevention trial based on lifestyle intervention programs.

METHODS:

Prospective analysis of 1986 community-dwelling subjects (mean age 65 years, 47% females) with overweight/obesity and metabolic syndrome from the PREDIMED-Plus trial was conducted. Accelerometry-derived sleep duration and sleep variability and changes in average weight, body mass index (BMI), and waist circumference (WC) attained after 12-month interventions were analyzed.

RESULTS:

The adjusted difference in 12-month changes in weight and BMI in participants in the third tertile of sleep variability was 0.5 kg (95% CI 0.1 to 0.9; p = 0.021) and 0.2 kg/m2 (0.04 to 0.4; p = 0.015), respectively, as compared with participants in the first tertile. The adjusted difference in 12-month changes from baseline in WC was -0.8 cm (-1.5 to -0.01; p = 0.048) in participants sleeping <6 h, compared with those sleeping between 7 and 9 h.

CONCLUSIONS:

Our findings suggest that the less variability in sleep duration or an adequate sleep duration the greater the success of the lifestyle interventions in adiposity.

PMID:
31217539
DOI:
10.1038/s41366-019-0401-5

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