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Int J Food Sci Nutr. 2020 Mar;71(2):152-163. doi: 10.1080/09637486.2019.1627515. Epub 2019 Jun 18.

Impact of quercetin on systemic levels of inflammation: a meta-analysis of randomised controlled human trials.

Author information

1
Department of Clinical Nutrition, The First Affiliated Hospital of Clinical Medicine of Guangdong Pharmaceutical University, Guangzhou, PR China.
2
Huangpu Customs District People's Republic of China, Guangzhou, PR China.

Abstract

Knowledge regarding the anti-inflammatory capability of quercetin remains inconclusive and controversial due to the heterogeneous methods and inconsistent results of RCTs. We performed a series of meta-analyses of RCTs to evaluate the impact of quercetin supplementation on inflammatory biomarkers. Three cytokines (CRP, IL-6, TNF-α) with enough eligible studies (n = 6, 5 and 4, respectively) were selected for further meta-analyses. Data from these RCTs were pooled, and both overall effect and stratified subgroup analyses were performed. No relevant overall effects on peripheral CRP, IL-6 and TNF-α were observed. Subgroup analyses revealed a significant reduction in circulating CRP in participants with diagnosed diseases (SMD: -0.24, 95% CI: -0.49, 0.00) and IL-6 in females (SMD: -1.37, 95% CI: -1.93, -0.81), subjects with diagnosed diseases (SMD: -1.37, 95% CI: -1.93, -0.81) and with high-dose interventions (SMD: -0.69, 95% CI: -1.10, -0.38). In conclusion, consumption of quercetin is a promising therapeutic strategy for chronic disease management.

KEYWORDS:

CRP; IL-6; Quercetin; TNF-α; inflammatory disease; meta-analysis

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