Send to

Choose Destination
Int J Food Sci Nutr. 2020 Mar;71(2):152-163. doi: 10.1080/09637486.2019.1627515. Epub 2019 Jun 18.

Impact of quercetin on systemic levels of inflammation: a meta-analysis of randomised controlled human trials.

Author information

Department of Clinical Nutrition, The First Affiliated Hospital of Clinical Medicine of Guangdong Pharmaceutical University, Guangzhou, PR China.
Huangpu Customs District People's Republic of China, Guangzhou, PR China.


Knowledge regarding the anti-inflammatory capability of quercetin remains inconclusive and controversial due to the heterogeneous methods and inconsistent results of RCTs. We performed a series of meta-analyses of RCTs to evaluate the impact of quercetin supplementation on inflammatory biomarkers. Three cytokines (CRP, IL-6, TNF-α) with enough eligible studies (n = 6, 5 and 4, respectively) were selected for further meta-analyses. Data from these RCTs were pooled, and both overall effect and stratified subgroup analyses were performed. No relevant overall effects on peripheral CRP, IL-6 and TNF-α were observed. Subgroup analyses revealed a significant reduction in circulating CRP in participants with diagnosed diseases (SMD: -0.24, 95% CI: -0.49, 0.00) and IL-6 in females (SMD: -1.37, 95% CI: -1.93, -0.81), subjects with diagnosed diseases (SMD: -1.37, 95% CI: -1.93, -0.81) and with high-dose interventions (SMD: -0.69, 95% CI: -1.10, -0.38). In conclusion, consumption of quercetin is a promising therapeutic strategy for chronic disease management.


CRP; IL-6; Quercetin; TNF-α; inflammatory disease; meta-analysis

Supplemental Content

Full text links

Icon for Taylor & Francis
Loading ...
Support Center