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Sensors (Basel). 2019 Jun 17;19(12). pii: E2719. doi: 10.3390/s19122719.

Analysis of Human Breath by Millimeter-Wave/Terahertz Spectroscopy.

Author information

1
Institute of Optical Sensor Systems, German Aerospace Center (DLR), 12489 Berlin, Germany. nick.rothbart@dlr.de.
2
Department of Physics, Humboldt-Universität zu Berlin, 12489 Berlin, Germany. nick.rothbart@dlr.de.
3
Fraunhofer Institute for Toxicology and Experimental Medicine ITEM, Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), 30625 Hannover, Germany. olaf.holz@item.fraunhofer.de.
4
The German Center for Lung Research (DZL), 35392 Giessen, Germany. olaf.holz@item.fraunhofer.de.
5
The German Center for Lung Research (DZL), 35392 Giessen, Germany. rkoczulla@schoen-klinik.de.
6
Department of Pulmonology, Institute for Internal Medicine, Philipps-University of Marburg, 35043 Marburg, Germany. rkoczulla@schoen-klinik.de.
7
Schön Klinik Berchtesgadener Land, Department for Pulmonology, Teaching Hospital of the Philipps-University, 35043 Marburg, Germany. rkoczulla@schoen-klinik.de.
8
Teaching Department of the Paracelsus University Salzburg, 5020 Salzburg, Austria. rkoczulla@schoen-klinik.de.
9
IHP-Leibniz-Institut für innovative Mikroelektronik, 15236 Frankfurt (Oder), Germany. schmalz@ihp-microelectronics.com.
10
Institute of Optical Sensor Systems, German Aerospace Center (DLR), 12489 Berlin, Germany. heinz-wilhelm.huebers@dlr.de.
11
Department of Physics, Humboldt-Universität zu Berlin, 12489 Berlin, Germany. heinz-wilhelm.huebers@dlr.de.

Abstract

Breath gas analysis is a promising tool for medical research and diagnosis. A particularly powerful technological approach is millimeter-wave/terahertz (mmW/THz) spectroscopy, because it is a very sensitive and highly selective technique. In addition, it offers the potential for compact and affordable sensing systems for wide use. In this work, we demonstrate the capability of a mmW/THz spectrometer for breath analysis. Samples from three volunteers and a sample from ambient air were analyzed with respect to 31 different molecular species. High-resolution absorption spectra were measured by scanning two absorption lines from each species. Out of the 31, a total of 21 species were detected. The results demonstrate the potential of mmW/THz spectroscopy for breath analysis.

KEYWORDS:

breath analysis; gas sensing; millimeter-wave; molecular spectroscopy; spectroscopy; terahertz

PMID:
31212999
DOI:
10.3390/s19122719
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