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Viruses. 2019 Jun 11;11(6). pii: E541. doi: 10.3390/v11060541.

The Interplay between Host Innate Immunity and Hepatitis E Virus.

Li Y1,2, Qu C3, Yu P4, Ou X5, Pan Q6,7, Wang W8,9.

Author information

1
China-Malaysia National Joint Laboratory, Biomedical Research Center, Northwest Minzu University, Lanzhou 730030, China. y.li.2@erasmusmc.nl.
2
Postgraduate School Molecular Medicine, Erasmus MC-University Medical Center, 3015 CN Rotterdam, The Netherlands. y.li.2@erasmusmc.nl.
3
Postgraduate School Molecular Medicine, Erasmus MC-University Medical Center, 3015 CN Rotterdam, The Netherlands. c.qu@erasmusmc.nl.
4
Postgraduate School Molecular Medicine, Erasmus MC-University Medical Center, 3015 CN Rotterdam, The Netherlands. p.yu@erasmusmc.nl.
5
Postgraduate School Molecular Medicine, Erasmus MC-University Medical Center, 3015 CN Rotterdam, The Netherlands. x.ou@erasmusmc.nl.
6
China-Malaysia National Joint Laboratory, Biomedical Research Center, Northwest Minzu University, Lanzhou 730030, China. q.pan@erasmusmc.nl.
7
Postgraduate School Molecular Medicine, Erasmus MC-University Medical Center, 3015 CN Rotterdam, The Netherlands. q.pan@erasmusmc.nl.
8
Postgraduate School Molecular Medicine, Erasmus MC-University Medical Center, 3015 CN Rotterdam, The Netherlands. w.wang.2@erasmusmc.nl.
9
Department of Infectious Diseases, Molecular Virology, University Hospital Heidelberg, 69120 Heidelberg, Germany. w.wang.2@erasmusmc.nl.

Abstract

Hepatitis E virus (HEV) infection represents an emerging global health issue, whereas the clinical outcomes vary dramatically among different populations. The host innate immune system provides a first-line defense against the infection, but dysregulation may partially contribute to severe pathogenesis. A growing body of evidence has indicated the active response of the host innate immunity to HEV infection both in experimental models and in patients. In turn, HEV has developed sophisticated strategies to counteract the host immune system. In this review, we aim to comprehensively decipher the processes of pathogen recognition, interferon, and inflammatory responses, and the involvement of innate immune cells in HEV infection. We further discuss their implications in understanding the pathogenic mechanisms and developing antiviral therapies.

KEYWORDS:

Hepatitis E virus; Inflammation; Innate immunity; Interferon

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