Format

Send to

Choose Destination
PLoS One. 2019 Jun 18;14(6):e0218075. doi: 10.1371/journal.pone.0218075. eCollection 2019.

Lipid profile is associated with decreased fatigue in individuals with progressive multiple sclerosis following a diet-based intervention: Results from a pilot study.

Author information

1
Department of Pharmaceutical Sciences, State University of New York, Buffalo, New York, United States of America.
2
Department of Internal Medicine, University of Iowa, Iowa City, Iowa, United States of America.
3
Department of Neurology, University of Iowa, Iowa City, Iowa, United States of America.
4
Department of Biotechnical and Clinical Laboratory Sciences, State University of New York, Buffalo, New York, United States of America.
5
Department of Epidemiology, University of Iowa, Iowa City, Iowa, United States of America.
6
Department of Neurology, State University of New York, Buffalo, New York, United States of America.

Abstract

PURPOSE:

To investigate associations between lipid profiles and fatigue in a cohort of progressive multiple sclerosis (MS) patients on a diet-based multimodal intervention.

METHODS:

This pilot study included 18 progressive MS patients who participated in a prospective longitudinal study of fatigue following a diet-based multimodal intervention that included exercise, neuromuscular electrical stimulation and stress reduction. The diet recommended high intake of vegetables and fruits, encouraged consumption of animal and plant protein and excluded foods with gluten-containing grains, dairy and eggs. Fatigue was measured on the Fatigue Severity Scale (FSS) at baseline and every 3 months for 12 months. A lipid profile consisting of high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC) and triglycerides (TG) was obtained on fasting blood samples at baseline and 12 months.

RESULTS:

FSS scores decreased from a baseline of 5.51 (95% CI: 4.86, 6.16) to a mean of 3.03 (95% CI: 2.23, 3.82) at 12 months (p < 0.001). At 12 months, increases in HDL-C (mean change: +6.0 mg/dl; 95% CI: 0.3, 12.0; p = 0.049) and decreases in BMI (mean change: -2.6 kg/m2; 95% CI: -3.6, -2.5; p < 0.001), LDL-C (mean change: -10.4 mg/dl; 95% CI:-19.7, -1.2; p = 0.029), TG (mean change: -29.2 mg/dl; 95% CI: -44.3, -14.2; p = 0.001), TG to HDL-C ratio (mean change: -0.6; 95% CI: -1.0, -0.3; p = 0.002) and TC to HDL-C ratio (mean change:-0.6; 95% CI: -1.0, -0.3; p = 0.003) were observed compared to baseline. Improvements in FSS were associated with increases in HDL-C (β = -0.05; 95% CI: -0.1, -0.0004; p = 0.048) and changes in TC (p = 0.005) from baseline to 12 months.

CONCLUSIONS:

Lipid profile variables are associated with improvements in fatigue in progressive MS patients on a diet-based multimodal intervention.

Conflict of interest statement

DJO Inc. provided in-kind support for the use of electrotherapy devices and electrode. Pinnaclife Inc. provided study vitamins and supplements. TZ Press LLC provided print materials. This does not alter our adherence to PLOS One policies on sharing data and materials. Dr. Terry L Wahls owns the copyrights to the books Minding My Mitochondria, 2nd Edition, The Wahls Protocol: A Radical New Way to Treat All Chronic Autoimmune Conditions Using Paleo Principles, and The Wahls Protocol Cooking for Life: The Revolutionary Modern Paleo Plan to Treat All Chronic Autoimmune Conditions. Dr. Wahls has research funding from the National Multiple Sclerosis Society and has financial relationships with Penguin Random House Inc., Integrative Medicine for Mental Health, Institute for Health and Healing, Suttler Pacific, BioCeuticals, NCURA, MCG Health Inc., Genova Diagnostics and Metagenics Institute. Dr. Wahls has also trademarked the following terms: Wahls™ Diet, Wahls Paleo™ Diet, Wahls Paleo Plus™ Diet, Wahls Protocol® and has equity interest in TZ Press, LLC, Dr. Terry Wahls, LLC, The Wahls Institute, PLC, and the website www.terrywahls.com. Conflict of interest management plans have been completed and are on file with the University of Iowa and the Iowa City Veterans Affairs Health Care System.

Supplemental Content

Full text links

Icon for Public Library of Science Icon for PubMed Central
Loading ...
Support Center