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J Altern Complement Med. 2019 Aug;25(8):833-839. doi: 10.1089/acm.2019.0061. Epub 2019 Jun 18.

Citrus aurantium Aroma for Anxiety in Patients with Acute Coronary Syndrome: A Double-Blind Placebo-Controlled Trial.

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1Traditional Medicine Clinical Trial Research Center, Faculty of Nursing and Midwifery, Shahed University, Tehran, Iran.
2Traditional Medicine Clinical Trial Research Center, Shahed University, Tehran, Iran.
3Department of Biostatistics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
4Cardiovascular Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
5Department of Nursing, Faculty of Nursing and Midwifery, Shahed University, Tehran, Iran.


Objective: This study evaluated the antianxiety effect of Citrus aurantium aroma (neroli oil) inhalation on patients with acute coronary syndrome (ACS). Design: A double-blind, placebo-controlled randomized trial. Setting/Location: This study was conducted in the Coronary Care Unit of Torfeh Hospital in Tehran, Iran, from September 2017 to February 2018. Subjects: A total of 140 hospitalized ACS patients (mean age = 56.72 ± 11.38 years) Interventions: Eligible patients were randomly assigned to citrus aroma and placebo groups to receive inhalation aromatherapy 2 days after hospitalization. Citrus aroma was 30% essential oil of Citrus aurantium L. flowers in paraffin, which was administrated three times a day. The placebo group received paraffin similarly. Outcome measures: The rate of anxiety was measured at baseline and after intervention using the State-Trait Anxiety Inventory. Results: At baseline, citrus aroma and placebo groups were similar in demographic characteristics as well as anxiety scores. After intervention, mean anxiety scores in the two groups become significantly different; the scores were 34.66 ± 9.6 and 42.36 ± 6.4 for citrus aroma and placebo groups, respectively (p < 0.0001). No side effect was observed. Conclusions: According to the current findings, aromatherapy with Citrus aurantium L. aroma (neroli oil) may be a safe and efficient intervention and can be considered an easy and applicable method to reduce anxiety in patients with ACS.


L; acute coronary syndrome; anxiety; aromatherapy; neroli oil; traditional Persian medicine

[Indexed for MEDLINE]

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