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Mol Cell Oncol. 2019 May 8;6(4):1607458. doi: 10.1080/23723556.2019.1607458. eCollection 2019.

FBXW2 suppresses proliferation and invasion of lung cancer cells by targeting SKP2 and β-catenin.

Author information

1
Cancer Institute of the Second Affiliated Hospital, and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China.
2
Division of Radiation and Cancer Biology, Departments of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.

Abstract

F-box protein is a substrate-receptor of SKP1-Cullin1-F-box protein (SCF) E3 ligase, but the function of many family members remains elusive. We found that F-box and WD-repeat domain-containing 2 (FBXW2) inhibits proliferation and invasion of lung cancer cells by targeting S phase kinase-associated protein 2 (SKP2) and β-catenin for degradation. Lower FBXW2 predicts a worse patient survival. Thus, FBXW2 appears a lung tumor suppressor.

KEYWORDS:

FBXW2; Lung cancer; SKP2; proliferation and invasion; ubiquitylation and degradation; β-catenin

PMID:
31211237
PMCID:
PMC6548489
[Available on 2020-05-08]
DOI:
10.1080/23723556.2019.1607458

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