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United European Gastroenterol J. 2019 Jun;7(5):583-613. doi: 10.1177/2050640619844125. Epub 2019 Apr 13.

European Society for the Study of Coeliac Disease (ESsCD) guideline for coeliac disease and other gluten-related disorders.

Author information

1
Department of Gastroenterology, St. Antonius Hospital, Nieuwegein, The Netherlands.
2
Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
3
Department of Translational Medical Science, Section of Paediatrics, University of Naples, Naples, Italy.
4
Department of Paediatric Gastroenterology, Hospital Universitari Sant Joan de Reus, Universitat Rovira I Virgili, IISPV, Reus, Spain.
5
Gastroenterology and Liver Unit, Royal Hallamshire Hospital & University of Sheffield, Sheffield, UK.
6
Gastroenterology Department, Hôpital Européen Georges Pompidou, Paris, France.
7
Department of Gastroenterology, VU Medical Centre, Amsterdam, The Netherlands.
8
Department of Gastroenterology, Oslo University Hospital Rikshospitalet, Oslo, Norway.
9
KG Jebsen Coeliac Disease Research Centre, University of Oslo, Oslo, Norway.

Abstract

This guideline presents recommendations for the management of coeliac disease (CD) and other gluten-related disorders both in adults and children. There has been a substantial increase in the prevalence of CD over the last 50 years and many patients remain undiagnosed. Diagnostic testing, including serology and biopsy, should be performed on a gluten-containing diet. The diagnosis of CD is based on a combination of clinical, serological and histopathological data. In a group of children the diagnosis may be made without biopsy if strict criteria are available. The treatment for CD is primarily a gluten-free diet (GFD), which requires significant patient education, motivation and follow-up. Slow-responsiveness occurs frequently, particularly in those diagnosed in adulthood. Persistent or recurring symptoms necessitate a review of the original diagnosis, exclude alternative diagnoses, confirm dietary adherence (dietary review and serology) and follow-up biopsy. In addition, evaluation to exclude complications of CD, such as refractory CD or lymphoma, should be performed. The guideline also deals with other gluten-related disorders, such as dermatitis herpetiformis, which is a cutaneous manifestation of CD characterized by granular IgA deposits in the dermal papillae. The skin lesions clear with gluten withdrawal. Also, less well-defined conditions such as non-coeliac gluten sensitivity (NCGS) and gluten-sensitive neurological manifestations, such as ataxia, have been addressed. Newer therapeutic modalities for CD are being studied in clinical trials but are not yet approved for use in practice.

KEYWORDS:

Coeliac disease; coeliac neuropathy; dermatitis herpetiformis; enteropathy associated T-cell lymphoma; gluten ataxia; neurocoeliac; non-coeliac gluten sensitivity; refractory coeliac disease; seronegative coeliac disease; slow-responder coeliac

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