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Ther Adv Med Oncol. 2019 Jun 3;11:1758835919853449. doi: 10.1177/1758835919853449. eCollection 2019.

SOX11: friend or foe in tumor prevention and carcinogenesis?

Author information

1
Department of Cardiovascular Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, China.
2
Department of Aerospace Medicine, The Fourth Military Medical University, Xi'an, China.
3
Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences, Northwest University, Xi'an, China.
4
Department of Biomedical Engineering, The Fourth Military Medical University, Xi'an, China.
5
Department of Immunology, The Fourth Military Medical University, Xi'an, China.
6
Department of Cardiovascular Surgery, Xijing Hospital, The Fourth Military Medical University, 127 Changle West Road, Xi'an 710032, China.

Abstract

Sex-determining region Y-related high-mobility-group box transcription factor 11 (SOX11) is an essential member of the SOX transcription factors and has been highlighted as an important regulator in embryogenesis. SOX11 studies have only recently shifted focus from its role in embryogenesis and development to its function in disease. In particular, the role of SOX11 in carcinogenesis has become of major interest in the field. SOX11 expression is elevated in a wide variety of tumors. In many cancers, dysfunctional expression of SOX11 has been correlated with increased cancer cell survival, inhibited cell differentiation, and tumor progression through the induction of metastasis and angiogenesis. Nevertheless, in a limited number of malignancies, SOX11 has also been identified to function as a tumor suppressor. Herein, we review the correlation between the expression of SOX11 and tumor behaviors. We also summarize the mechanisms underlying the regulation of SOX11 expression and activity in pathological conditions. In particular, we focus on the pathological processes of cancer targeted by SOX11 and discuss whether SOX11 is protective or detrimental during tumor progression. Moreover, SOX11 is highlighted as a clinical biomarker for the diagnosis and prognosis of various human cancer. The information reviewed here should assist in future experimental designs and emphasize the potential of SOX11 as a therapeutic target for cancer.

KEYWORDS:

SOX11; biomarker; cancer; cell differentiation; cell proliferation; metastasis; prognosis

Conflict of interest statement

Conflict of interest statement: The authors declare that there is no conflict of interest.

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