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Br J Dermatol. 2019 Jun 18. doi: 10.1111/bjd.18228. [Epub ahead of print]

Curcumin suppresses IL-6 production in THP-1 monocytes induced by Propionibacterium acnes extracts via down-regulation of TLR2 expression and the NF-κB pathway.

Xu C1, Zeng R1, Chen Q2,3, Du L1, Tong J1, He Y1, Xu H1, Li M1,3.

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Institute of Dermatology, Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Chinese Academy of Medical Science & Peking Union Medical College, Nanjing, 210042, China.
Jiangsu Province Blood Center, Nanjing, Jiangsu, 210042, China.
Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, 211166, China.


Acne vulgaris is a common chronic inflammatory skin disorder, affecting approximately 80% of adolescents.1 Propionibacterium acnes (P. acnes) is one of the factors possibly playing a role in acne pathophysiology. It induces monocytes and keratinocytes to secrete pro-inflammatory cytokines, including interleukin (IL)-6, IL-8, and tumor necrosis factor-α, via activation of the toll like receptor (TLR) 2 signaling pathway.2,3 IL-6 is one important adipokine participating in the pathogenesis of acne inflammation, and its secretion depending on TLR2-NF-κB pathway results in influx of other inflammatory cells and disruption of sebaceous gland homeostasis. This article is protected by copyright. All rights reserved.


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