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Br J Dermatol. 2019 Jun 18. doi: 10.1111/bjd.18228. [Epub ahead of print]

Curcumin suppresses IL-6 production in THP-1 monocytes induced by Propionibacterium acnes extracts via down-regulation of TLR2 expression and the NF-κB pathway.

Xu C1, Zeng R1, Chen Q2,3, Du L1, Tong J1, He Y1, Xu H1, Li M1,3.

Author information

1
Institute of Dermatology, Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Chinese Academy of Medical Science & Peking Union Medical College, Nanjing, 210042, China.
2
Jiangsu Province Blood Center, Nanjing, Jiangsu, 210042, China.
3
Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, 211166, China.

Abstract

Acne vulgaris is a common chronic inflammatory skin disorder, affecting approximately 80% of adolescents.1 Propionibacterium acnes (P. acnes) is one of the factors possibly playing a role in acne pathophysiology. It induces monocytes and keratinocytes to secrete pro-inflammatory cytokines, including interleukin (IL)-6, IL-8, and tumor necrosis factor-α, via activation of the toll like receptor (TLR) 2 signaling pathway.2,3 IL-6 is one important adipokine participating in the pathogenesis of acne inflammation, and its secretion depending on TLR2-NF-κB pathway results in influx of other inflammatory cells and disruption of sebaceous gland homeostasis. This article is protected by copyright. All rights reserved.

PMID:
31209872
DOI:
10.1111/bjd.18228

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