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J Clin Med. 2019 Jun 14;8(6). pii: E851. doi: 10.3390/jcm8060851.

Effect of Short Term Intensive Lifestyle Intervention on Hepatic Steatosis Indexes in Adults with Obesity and/or Type 2 Diabetes.

Author information

1
Healthy Lifestyle Institute, C.U.R.I.A.Mo (Centro Universitario Ricerca Interdipartimentale Attività Motoria), University of Perugia, Via G. Bambagioni, 19 06126 Perugia, Italy. elisa.reginato@gmail.com.
2
Healthy Lifestyle Institute, C.U.R.I.A.Mo (Centro Universitario Ricerca Interdipartimentale Attività Motoria), University of Perugia, Via G. Bambagioni, 19 06126 Perugia, Italy. robertopippi@gmail.com.
3
Healthy Lifestyle Institute, C.U.R.I.A.Mo (Centro Universitario Ricerca Interdipartimentale Attività Motoria), University of Perugia, Via G. Bambagioni, 19 06126 Perugia, Italy. cristina.aiello@hotmail.com.
4
Healthy Lifestyle Institute, C.U.R.I.A.Mo (Centro Universitario Ricerca Interdipartimentale Attività Motoria), University of Perugia, Via G. Bambagioni, 19 06126 Perugia, Italy. emilia.sbroma@virgilio.it.
5
Healthy Lifestyle Institute, C.U.R.I.A.Mo (Centro Universitario Ricerca Interdipartimentale Attività Motoria), University of Perugia, Via G. Bambagioni, 19 06126 Perugia, Italy. claudiaranucci.diet@gmail.com.
6
Healthy Lifestyle Institute, C.U.R.I.A.Mo (Centro Universitario Ricerca Interdipartimentale Attività Motoria), University of Perugia, Via G. Bambagioni, 19 06126 Perugia, Italy. liviaburatta@hotmail.it.
7
Department of Medicine, University of Perugia, 06126 Perugia, Italy. vittorio.bini@unipg.it.
8
Unit of Metabolic Diseases and Clinical Dietetics, Alma Mater University of Bologna, 40126 Bologna, Italy. giulio.marchesini@unibo.it.
9
Healthy Lifestyle Institute, C.U.R.I.A.Mo (Centro Universitario Ricerca Interdipartimentale Attività Motoria), University of Perugia, Via G. Bambagioni, 19 06126 Perugia, Italy. pierpaolodefeo@gmail.com.
10
Healthy Lifestyle Institute, C.U.R.I.A.Mo (Centro Universitario Ricerca Interdipartimentale Attività Motoria), University of Perugia, Via G. Bambagioni, 19 06126 Perugia, Italy. carmine.fanelli@unipg.it.

Abstract

BACKGROUND:

Non-alcoholic fatty liver disease (NAFLD) has an estimated prevalence of 20-30% in the general population and even higher in individuals with metabolic risk factors. The aim of this study was to evaluate the effect of a lifestyle intervention program on surrogate markers of hepatic steatosis in obesity and/or type 2 diabetes patients, enrolled in the C.U.R.I.A.Mo. (Centro Universitario di Ricerca Interdipartimentale Attività Motoria) trial.

METHODS:

102 subjects (56 females and 46 males, aged between 23 and 78) with type 2 diabetes, obesity or a BMI of at least 25 kg/m2 with comorbidities, participated in the intensive phase of a multidisciplinary lifestyle intervention program at the Healthy Lifestyle Institute of the University of Perugia (C.U.R.I.A.Mo.). Six indices related to NAFLD (Visceral Adiposity Index, Fatty Liver index, Non-Alcoholic Fatty Liver Disease liver fat score and liver fat equation, hepatic steatosis index and TyG index) were calculated before and after a three-month multidisciplinary lifestyle intervention.

RESULTS:

The intervention improved the anthropometric and clinical parameters in the total population, the obese and/or diabetics. Data showed a significant weight loss, a reduced waist circumference, triglycerides, and an improvement in Mediterranean diet adherence. Hepatic steatosis indices were significantly reduced in the total population and in different subgroups (males, females, obesity and diabetes).

KEYWORDS:

Non-alcoholic fatty liver disease; exercise; lifestyle; obesity; type 2 diabetes mellitus

Conflict of interest statement

The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.

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