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Viruses. 2019 Jun 14;11(6). pii: E554. doi: 10.3390/v11060554.

Hepatitis E Virus Infections among Patients with Acute Febrile Jaundice in Burkina Faso.

Author information

1
Laboratoire de virologie, Centre national de référence du virus de l'hépatite E, CHU Toulouse, Hôpital Purpan, 31300 Toulouse, France. dimeglio.c@chu-toulouse.fr.
2
Centre MURAZ, Bobo-Dioulasso, Burkina Faso. draka3703@yahoo.fr.
3
Centre MURAZ, Bobo-Dioulasso, Burkina Faso. mantonochancelvie@yahoo.fr.
4
Université Catholique d'Afrique de l'Ouest, Bobo-Dioulasso, Burkina Faso. mantonochancelvie@yahoo.fr.
5
Centre MURAZ, Bobo-Dioulasso, Burkina Faso. tskagone@gmail.com.
6
Centre MURAZ, Bobo-Dioulasso, Burkina Faso. zida_sylvie@yahoo.fr.
7
Institut de recherche en sciences de la santé (IRSS), Ouagadougou, Burkina Faso. zida_sylvie@yahoo.fr.
8
Centre MURAZ, Bobo-Dioulasso, Burkina Faso. tassoulee@yahoo.fr.
9
Centre MURAZ, Bobo-Dioulasso, Burkina Faso. dicko22@gmail.com.
10
Centre MURAZ, Bobo-Dioulasso, Burkina Faso. tintobachirou@yahoo.fr.
11
Centre MURAZ, Bobo-Dioulasso, Burkina Faso. yaro_seydou@yahoo.com.
12
Centre MURAZ, Bobo-Dioulasso, Burkina Faso. hien_herve@hotmail.com.
13
Centre MURAZ, Bobo-Dioulasso, Burkina Faso. jeremirouamba@gmail.com.
14
Université Ouaga I Pr Joseph KI-ZERBO, Ouagadougou, Burkina Faso. jeremirouamba@gmail.com.
15
Institut de recherche en sciences de la santé (IRSS), Ouagadougou, Burkina Faso. bicaba_brico@yahoo.fr.
16
Ministère de la Santé, Ouagadougou, Burkina Faso. isaiemedah@yahoo.fr.
17
Ministère de la Santé, Ouagadougou, Burkina Faso. nicolas.meda@gmail.com.
18
Agence nationale de biosécurité, Ouagadougou, Burkina Faso. kourouda@gmail.com.
19
Pathogenesis and Control of Chronic Infections., Etablissement Français du Sang, CHU Montpellier, INSERM, University of Montpellier, 34090 Montpellier, France. e-tuaillon@chu-montpellier.fr.
20
Laboratoire de virologie, Centre national de référence du virus de l'hépatite E, CHU Toulouse, Hôpital Purpan, 31300 Toulouse, France. bravanel.f@chu-toulouse.fr.
21
Centre de Physiopathologie de Toulouse Purpan (CPTP), UMR Inserm, U1043, UMR CNRS, U5282, 31300 Toulouse, France. bravanel.f@chu-toulouse.fr.
22
Laboratoire de virologie, Centre national de référence du virus de l'hépatite E, CHU Toulouse, Hôpital Purpan, 31300 Toulouse, France. izopet.j@chu-toulouse.fr.
23
Centre de Physiopathologie de Toulouse Purpan (CPTP), UMR Inserm, U1043, UMR CNRS, U5282, 31300 Toulouse, France. izopet.j@chu-toulouse.fr.

Abstract

Hepatitis E virus infection is a significant public health problem in many parts of the world including Africa. We tested serum samples from 900 patients in Burkina Faso presenting with febrile icterus. They all tested negative for yellow fever, but those from 23/900 (2.6%) patients contained markers of acute HEV infection (anti-HEV IgM and HEV RNA positive). Genotyping indicated that 14 of the strains were HEV genotype 2b. There was an overall HEV IgG seroprevalence of 18.2% (164/900). In a bivariate analysis, the factors linked to HEV exposure were climate and patient age. Older patients and those living in arid regions were more likely to have HEV infection. HEV genotype 2b circulating only in humans can be involved in some acute febrile icterus cases in Burkina Faso. Better access to safe water, sanitation, and improved personal hygiene should improve control of HEV infection in this country.

KEYWORDS:

Burkina Faso; epidemiology; hepatitis E virus; risk factors

Conflict of interest statement

The authors declare no conflict of interest. The funders had no role in the design of the study, in the collection, analyses, or interpretation of data, in the writing of the manuscript, or in the decision to publish the results.

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