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Acta Haematol. 2019;142(2):87-91. doi: 10.1159/000495601. Epub 2019 Jun 17.

A Unique Case of Primary Extranodal Marginal Zone Lymphoma of the Anal Canal.

Author information

1
Department of Hematology, Laikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece.
2
Second Department of Surgery, Propedeutic, Laikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece.
3
Department of Nuclear Medicine and PET/CT, Evangelismos General Hospital, Athens, Greece.
4
Department of Haematology, Athens Navy Hospital, Athens, Greece.
5
Department of Pathology, National and Kapodistrian University of Athens, Athens, Greece.
6
Department of Hematopathology, Evangelismos General Hospital, Athens, Greece.
7
Department of Hematology, Laikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece, tvassilak@med.uoa.gr.

Abstract

Marginal zone lymphomas represent approximately 10-12% of all B-cell lymphomas. Extranodal marginal zone lymphomas (EMZL) or mucosa-associated lymphoid tissue (MALT) lymphomas are the most common subtype. Almost half of all MALT lymphomas arise in the gastrointestinal (GI) tract and, while the stomach is the most common site of GI involvement, the small and large intestines can also be involved. Rare cases of MALT lymphoma involving the rectum have been reported; however, to our knowledge, involvement of the anal canal has never been reported in the literature. Here, we describe a unique case of MALT lymphoma of the anal canal. Infectious agents have been implicated in the pathogenesis of MALT lymphomas, possibly through persistent antigenic stimulation of the area; however, in our case no such infection was documented.

KEYWORDS:

Anal canal; Extranodal marginal zone lymphoma; MALT lymphoma

PMID:
31207598
DOI:
10.1159/000495601

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