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J Cell Physiol. 2019 Jun 17. doi: 10.1002/jcp.28926. [Epub ahead of print]

Upregulation of lncRNA GAS5 inhibits the growth and metastasis of cervical cancer cells.

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Department of Gynaecology and Obstetrics, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.


This study aims to figure out the methylation of long non-coding RNA GAS5 promoter in cervical cancer and the mechanism of GAS5 on the progression of cervical cancer cells. The expression of GAS5 and methylation state of GAS5 in cervical cancer tissues and cells were determined. With the aim to to explore the ability of GAS5 in the proliferation, cell cycle progression, apoptosis, invasion, migration as well as the tumor growth, and metastasis in nude mice were determined. The expression of GAS5 was decreased and methylation state of GAS5 was elevated in cervical cancer. Overexpression of GAS5 inhibited proliferation, cell cycle progression, invasion, migration while inducing apoptosis of cervical cancer cells as well as suppressed tumor growth and metastasis in nude mice. Our study demonstrates that abnormal methylation of GAS5 contributes to poor expression of GAS5 in cervical cancer. In addition, upregulation of GAS5 inhibits the cervical cancer development.


GAS5; cervical cancer; growth; metastasis; promoter methylation


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