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Alzheimers Dement (Amst). 2019 Jun 6;11:405-414. doi: 10.1016/j.dadm.2019.04.003. eCollection 2019 Dec.

Perifovea retinal thickness as an ophthalmic biomarker for mild cognitive impairment and early Alzheimer's disease.

Author information

1
Department of Ophthalmology, Huashan Hospital, Fudan University, Shanghai, China.
2
Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
3
National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China.

Abstract

Introduction:

The aim of this study was to investigate retinal thickness as a biomarker for identifying patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD).

Methods:

The retinal thickness, utilizing the spectral domain optical coherence tomography, was compared among 73 patients with AD, 51 patients with MCI, 67 cognitive normal control (NC) subjects.

Results:

The retinal thickness of ganglion cell complex and peripapillary retinal nerve fiber layer decreased in both AD and MCI patients, in comparison with NC subjects (AD vs. NC, P < .01; MCI vs. NC, P < .01). The inner retinal layers in macular area in MCI exhibited significant thinning compared with NC (P < .001). Remarkable association was found between the retinal thickness and brain volume (P < .05). Better correlation was seen between the inner perifovea retinal thickness and the hippocampal and entorhinal cortex volume (r: 0.427-0.644, P < .01).

Discussion:

The retinal thickness, especially the inner retinal layer thickness, is a potentially early AD marker indicating neurodegeneration.

KEYWORDS:

Alzheimer's disease; Biomarker; Brain atrophy; Mild cognitive impairment; Retinal thickness

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