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Cell Metab. 2019 Jul 2;30(1):1-2. doi: 10.1016/j.cmet.2019.05.014. Epub 2019 Jun 13.

Treatment with Statins Does Not Revert Trained Immunity in Patients with Familial Hypercholesterolemia.

Author information

1
Department of Internal Medicine, and Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen 6525GA, the Netherlands; Department of Vascular Medicine, Amsterdam University Medical Centres, University of Amsterdam, 1105AZ Amsterdam, the Netherlands.
2
Department of Vascular Medicine, Amsterdam University Medical Centres, University of Amsterdam, 1105AZ Amsterdam, the Netherlands.
3
Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, 3052 Victoria, Australia.
4
Experimental Vascular Biology, Department of Medical Biochemistry, Amsterdam University Medical Centres, University of Amsterdam, 1105AZ Amsterdam, the Netherlands.
5
Department of Internal Medicine, Erasmus University Medical Center, 3015GD Rotterdam, the Netherlands.
6
Department of Molecular Biology, RIMLS, Radboud University Medical Center, Nijmegen 6525GA, the Netherlands.
7
Experimental Vascular Biology, Department of Medical Biochemistry, Amsterdam University Medical Centres, University of Amsterdam, 1105AZ Amsterdam, the Netherlands; Institute for Cardiovascular Prevention (IPEK), 80336 Munich, Germany.
8
Department of Internal Medicine, and Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen 6525GA, the Netherlands; Department of Medical Genetics, "Iuliu Haţieganu" University of Medicine and Pharmacy, 400000 Cluj-Napoca, Romania.
9
Department of Internal Medicine, and Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen 6525GA, the Netherlands; Department for Immunology & Metabolism, Life and Medical Sciences Institute (LIMES), University of Bonn, 53115 Bonn, Germany.
10
Department of Internal Medicine, and Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen 6525GA, the Netherlands. Electronic address: niels.riksen@radboudumc.nl.

Abstract

Individuals with elevated LDL-cholesterol levels have an increased risk for cardiovascular disease. Despite lipid lowering strategies, however, a significant cardiovascular risk remains. Bekkering et al. show that monocytes from patients with familial hypercholesterolemia have a trained immunity phenotype and that lipid lowering with statins does not revert this pro-inflammatory phenotype.

PMID:
31204280
DOI:
10.1016/j.cmet.2019.05.014

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