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Analyst. 2019 Jun 14. doi: 10.1039/c9an00558g. [Epub ahead of print]

True one cell chemical analysis: a review.

Author information

1
Department of Chemistry, University of North Texas, Denton, TX 76201, USA. gverbeck@unt.edu.
2
University of Surrey, Guildford, Surrey GU2 7XH, UK.

Abstract

The constantly growing field of True One Cell (TOC) analysis has provided important information on the direct chemical composition of various cells and cellular components. Since the heterogeneity of individual cells has been established, more researchers are interested in the chemical differences between individual cells; TOC is the only form of analysis that can provide this information. This has resulted in the constant development of new technologies and methods. This review highlights the common techniques for micro- and nanomanipulation, Raman spectroscopy, microscopy, and mass spectrometric imaging as they pertain to TOC chemical analysis.

PMID:
31199412
DOI:
10.1039/c9an00558g

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