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Am J Physiol Heart Circ Physiol. 2019 Aug 1;317(2):H375-H386. doi: 10.1152/ajpheart.00206.2019. Epub 2019 Jun 14.

Macrophages and T cells in atherosclerosis: a translational perspective.

Author information

1
Department of Advanced Clinical and Translational Cardiovascular Imaging, Harry Perkins Institute of Medical Research, Murdoch, Western Australia, Australia.
2
School of Medicine, University of Western Australia, Perth, Western Australia, Australia.
3
Heart Research Institute, Sydney Medical School, University of Sydney, Sydney, Australia.
4
Department of Microbiology, Pathwest Laboratory Medicine, Perth, Western Australia, Australia.
5
Department of Cardiology, Fiona Stanley Hospital, Murdoch, Western Australia, Australia.

Abstract

Atherosclerosis is now considered a chronic maladaptive inflammatory disease. The hallmark feature in both human and murine disease is atherosclerotic plaques. Macrophages and various T-cell lineages play a crucial role in atherosclerotic plaque establishment and disease progression. Humans and mice share many of the same processes that occur within atherogenesis. The various similarities enable considerable insight into disease mechanisms and those which contribute to cardiovascular complications. The apolipoprotein E-null and low-density lipoprotein receptor-null mice have served as the foundation for further immunological pathway manipulation to identify pro- and antiatherogenic pathways in attempt to reveal more novel therapeutic targets. In this review, we provide a translational perspective and discuss the roles of macrophages and various T-cell lineages in contrasting proatherosclerotic and atheroprotective settings.

KEYWORDS:

T cells; atherogenesis; atherosclerosis; macrophages

PMID:
31199186
DOI:
10.1152/ajpheart.00206.2019
[Indexed for MEDLINE]

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