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J Clin Lab Anal. 2019 Jun 14:e22950. doi: 10.1002/jcla.22950. [Epub ahead of print]

The association between the ApoE polymorphisms and the MRI-defined intracranial lesions in a cohort of southern China population.

Author information

1
Department of Radiology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China.
2
Department of Laboratory Medicine, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China.
3
Guangzhou University of Chinese Medicine, Guangzhou, China.

Abstract

BACKGROUND:

The apolipoprotein E (APOE) ε4 allele is considered as a risk factor for Alzheimer's disease (AD). However, the association of APOE allele with MRI evidence of intracranial lesions has not been well understood.

METHODS:

Quantitative real-time PCR was performed to detect the APOE genotype; MRI was examined for intracranial lesions. Their association was evaluated in a cohort of 226 AD patients and 2607 healthy individuals in southern China.

RESULTS:

The frequencies of ε2, ε3, and ε4 alleles were 8.0%, 82.9%, and 9.1% in the whole study population. The frequency of APOE-ε4 allele was significantly higher in the AD subjects than that in the control group (14.4% vs 8.6%, P < 0.001). We found that brain atrophy occurred at a rate of 12.3% in ε4 allele group vs 8.5% in non-ε4 genotype group, with a significance of P = 0.008. Severe brain atrophy occurred at a rate of 1.0% in ε4 allele group vs 0.2% in non-ε4 genotype group (P = 0.011). The individuals carrying APOE ε4/ε4 had an odds ratio (OR) of 7.64 (P < 0.01) for developing AD, while the APOE ε3/ε4 gene carriers had an OR of 1.47 (P = 0.031) and the OR in APOE ε2/ε3 carriers is 0.81 (P = 0.372). Interestingly, we found that the risk of ε4/ε4 allele carrier developing AD was significantly higher in male (P < 0.001) than female (P = 0.478).

CONCLUSION:

Compared to ε2 and ε3 alleles, the presence of APOE-ε4 allele might increase the risk for AD in a dose-dependent manner in southern China. Moreover, the presence of APOE-ε4 allele results in a higher incidence of brain atrophy.

KEYWORDS:

apolipoprotein E gene; brain atrophy; gene polymorphisms; magnetic resonance imaging

PMID:
31199015
DOI:
10.1002/jcla.22950

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