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Int J Prev Med. 2019 May 17;10:68. doi: 10.4103/ijpvm.IJPVM_279_17. eCollection 2019.

Protective Effect of Zinc Supplementation on Renal Ischemia/Reperfusion Injury in Rat: Gender-related Difference.

Author information

1
Department of Physiology, Water and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
2
Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran.
3
IsfahanMN Institute of Basic and Applied Sciences Research, Isfahan, Iran.

Abstract

Background:

Zinc (Zn) knows as essential microelement which prevents oxidative stress. The effect of Zn supplement on renal function parameters in rats subjected to renal ischemia-reperfusion (IR) injury was investigated.

Methods:

Male and female rats were subjected to renal IR with and without Zn sulfate (10 mg/kg/day for 5 days) supplementation. The kidney function markers and histology findings in Zn-treated group were compared with sham and control groups.

Results:

The serum levels of blood urea nitrogen and creatinine (Cr) and kidney tissue damage score were increased significantly after renal injury (P < 0.05) gender dependently, but no alterations were observed for these markers in Zn-treated animals after renal IR injury. Cr clearance was significantly different between genders (P < 0.05); however, Zn supplementation increased the Cr clearance and kidney nitrite level significantly in male rats (P < 0.05). Zn also increased urine flow in female (P < 0.05), but it did not alter urine load of Na (UNaV) and percentage of Na excretion (ENa%).

Conclusions:

Zn may improve renal function after IR injury gender dependently.

KEYWORDS:

Gender; rats; renal ischemia-reperfusion; zinc

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