Format

Send to

Choose Destination
Int J Prev Med. 2019 May 17;10:64. doi: 10.4103/ijpvm.IJPVM_278_17. eCollection 2019.

Protective Role of Angiotensin Type 1 Receptor Blockade in 4/6 Nephrectomized Male and Female Rats.

Author information

1
Water and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
2
Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran.
3
Isfahan MN Institute of Basic and Applied Sciences Research, Isfahan, Iran.

Abstract

Background:

Chronic kidney disease associated with serious morbidity and mortality rate while it is affected by renin-angiotensin system. The effects of losartan as angiotensin II Type 1 receptor antagonist on renal functional in 4/6 nephrectomized rats was evaluated.

Methods:

Twenty-six male and female Wistar rats underwent 4/6 nephrectomy, and the animals from each gender were randomly divided into two groups which treated with vehicle and losartan (10 mg/kg/day for 1 week). The parameters related to kidney function were measured.

Results:

Creatinine (Cr) clearance and urine flow were improved in losartan-treated group significantly (P < 0.05). The serum level of blood urea nitrogen and Cr and kidney tissue damage score and sodium urinary output (UNaV) did not alter. However, losartan decreased percentage of sodium excretion (ENa%) in both genders insignificantly.

Conclusions:

Losartan may improve renal function in 4/6 nephrectomized male rats.

KEYWORDS:

Losartan; nephrectomy; rat

Supplemental Content

Full text links

Icon for Medknow Publications and Media Pvt Ltd Icon for PubMed Central
Loading ...
Support Center