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J Pharm Bioallied Sci. 2019 May;11(Suppl 2):S126-S130. doi: 10.4103/JPBS.JPBS_41_19.

Platelet-Rich Plasma and Platelet-Rich Fibrin in Periodontal Regeneration: A Review.

Author information

1
Department of Stem Cells and Regenerative Medicine, Sree Anjaneya Institute of Dental Sciences, Calicut, Kerala, India.
2
Department of Oral and Maxillofacial Pathology, Sree Anjaneya Institute of Dental Sciences, Calicut, Kerala, India.
3
Department of Oral Medicine and Radiology, Sree Anjaneya Institute of Dental Sciences, Calicut, Kerala, India.
4
Department of Oral Pathology and Microbiology, Indira Gandhi Institute of Dental Sciences, Sri Balaji Vidyapeeth Deemed To Be University, Pillayarkuppam, Puducherry, India.
5
Department of Periodontics, Sree Anjaneya Institute of Dental Sciences, Calicut, Kerala, India.

Abstract

Platelet concentrates (PCs; platelet-rich plasma and platelet-rich fibrin) are autologous bioactive substances that have found varied application in medical and dental fields, particularly in oral and maxillofacial surgery, plastic surgery, and sports medicine. The rationale of these technologies is to extract all the elements from patient's own blood sample, which could be used to improve healing by promoting tissue regeneration. PCs have evolved a long way since its introduction in 1954. PCs have been used successfully in periodontics and implant dentistry. However, the preparation protocol, processing time, transfer of concentrates, centrifugation temperature, vibration, etc., being not standardized are various factors for the mixed results reported in the literature. This review intends to discuss evolution of PCs, their preparation techniques, and their clinical and technical aspects and applications.

KEYWORDS:

Fibrin glue; leukocyte and platelet-rich fibrin; platelet concentrates; platelet-derived growth factors; platelet-rich fibrin; platelet-rich plasma; sticky bone

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