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Sci Rep. 2019 Jun 13;9(1):7727. doi: 10.1038/s41598-019-44193-4.

Lower Incidence Rate of Type 1 Diabetes after Receipt of the Rotavirus Vaccine in the United States, 2001-2017.

Author information

1
Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA. maryroge@umich.edu.
2
Institute of Healthcare Policy and Innovation, University of Michigan, Ann Arbor, USA. maryroge@umich.edu.
3
Institute of Healthcare Policy and Innovation, University of Michigan, Ann Arbor, USA.
4
Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.

Abstract

We evaluated whether rotavirus vaccination is associated with the incidence of type 1 diabetes among children. We designed a cohort study of 1,474,535 infants in the United States from 2001-2017, using data from a nationwide health insurer. There was a 33% reduction in the risk of type 1 diabetes with completion of the rotavirus vaccine series compared to the unvaccinated (95% CI: 17%, 46%). Completion of the pentavalent vaccine series was associated with 37% lower risk of type 1 diabetes (95% CI: 22%, 50%). Partial vaccination (incompletion of the series) was not associated with the incidence of type 1 diabetes. There was a 31% reduction in hospitalizations in the 60-day period after vaccination (95% CI: 27%, 35%) compared to unvaccinated children. Overall, there was a 3.4% decrease in incidence annually in children ages 0-4 in the United States from 2006-2017 which coincides with the vaccine introduction in 2006. We conclude that rotavirus vaccination is associated with a reduced incidence of type 1 diabetes. Rotavirus vaccination may be the first practical measure that could play a role in the prevention of this disease.

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