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Science. 2019 Jun 14;364(6445). pii: eaaw6732. doi: 10.1126/science.aaw6732.

A microbial factory for defensive kahalalides in a tripartite marine symbiosis.

Author information

1
Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
2
Princeton Center for Theoretical Science, Princeton University, Princeton, NJ 08544, USA.
3
Center for the Physics of Biological Function, Princeton University, Princeton, NJ 08544, USA.
4
Institute of Marine and Environmental Technology, University of Maryland Center for Environmental Science, Baltimore, MD 21202, USA.
5
Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA. donia@princeton.edu.

Abstract

Chemical defense against predators is widespread in natural ecosystems. Occasionally, taxonomically distant organisms share the same defense chemical. Here, we describe an unusual tripartite marine symbiosis, in which an intracellular bacterial symbiont ("Candidatus Endobryopsis kahalalidefaciens") uses a diverse array of biosynthetic enzymes to convert simple substrates into a library of complex molecules (the kahalalides) for chemical defense of the host, the alga Bryopsis sp., against predation. The kahalalides are subsequently hijacked by a third partner, the herbivorous mollusk Elysia rufescens, and employed similarly for defense. "Ca E. kahalalidefaciens" has lost many essential traits for free living and acts as a factory for kahalalide production. This interaction between a bacterium, an alga, and an animal highlights the importance of chemical defense in the evolution of complex symbioses.

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PMID:
31196985
DOI:
10.1126/science.aaw6732

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