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Nanomaterials (Basel). 2019 Jun 5;9(6). pii: E860. doi: 10.3390/nano9060860.

A Photocleavable Amphiphilic Prodrug Self-Assembled Nanoparticles with Effective Anticancer Activity In Vitro.

Author information

1
College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325027, China. 16451282234@stu.wzu.edu.cn.
2
College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325027, China. chemliguotao@sina.com.
3
College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325027, China. qihong.liu@pharmaron-bj.com.
4
Department of Pharmaceutics, School of Pharmacy, Qingdao University, Qingdao 266021, China. liangyan@qdu.edu.cn.
5
College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325027, China. mcl@wzu.edu.cn.
6
College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325027, China. huayuewu@wzu.edu.cn.
7
College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325027, China. wenxiag@wzu.edu.cn.

Abstract

Accelerating degradation of prodrug is an effective strategy for improving the pharmacological action. A photocleavable amphiphilic prodrug of methotrexate-coumarin derivative-PEG conjugates (MTX-AMC-PEG) with photo-triggered breakage to release clinical drug under laser irradiation was fabricated and self-assembled into nanoparticles for chemotherapy. The nanoparticles exhibited good intracellular uptake and excellent photolysis release of MTX, which resulted in efficient anticancer activity in vitro with laser irradiation. This research provides a way to fabricate photocleavable prodrug nanoparticles with stimuli-triggered drug release behavior.

KEYWORDS:

chemotherapy; methotrexate; photocleavable; prodrug; stimuli-responsive release

PMID:
31195730
DOI:
10.3390/nano9060860
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