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Int J Cosmet Sci. 2019 Jun 13. doi: 10.1111/ics.12550. [Epub ahead of print]

Association between Lactic Acid Sting Test Scores, Self-Assessed Sensitive Skin Score sand Biophysical Properties in Chinses Females.

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Department of Dermatology, First Affliated Hospital of Kunming Medical University and Institute of Dermatology & Venereology of Yunnan province, Kunming, 650032, China.
Dermatology Service, Veterans Affairs Medical Center, and Department of Dermatology, University of California, San Francisco, CA, USA.
Qujing Affliated Hospital of Kunming Medical University and Department of Dermatology, The First People's Hospital of Qujing, Qujing, 655000, China.
Department of Dermatology, People's Hospital of Chuxiong Yi Autonomous Prefecture, chuxiong, 675000, China.



Lactic acid sting test (LAST) is a classical method to identify sensitive skin. However, some subjects with self-perceived sensitive skins are negative for lactic acid sting test.


To determine whether LAST scores are associated with specific phenotype of sensitive skin.


A total of 292 subjects with self-perceived sensitive skin were enrolled in this study. The Sensitive Scale was used to evaluate the severity of burning, stinging, itching, tautness, erythema and scaling based on 0 to 10 scale scores. In addition to assessment of LAST scores, epidermal biophysical properties were measured with an MPA system.


The Sensitive Scale scores of stinging, itching, tautness and scaling were significantly different between LAST positive and negative group. However, burning and erythema scores did not differ between LAST positive and negative group. LAST scores correlated positively with stinging, itching, tautness and scaling Sensitive Scale scores, but not with burning and erythema scores. Moreover, LAST scores correlated negatively with stratum corneum hydration,but positively with TEWL rates.


LAST scores correlated positively with TEWL rates. LAST scores could be used to identify subjects with sensitive skin characterized mainly by stinging and itching, but not those mainly by burning and erythema. This article is protected by copyright. All rights reserved.


Epidermal permeability barrier; The Sensitive Scale; lactic acid sting test; sensitive skin


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