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J Med Primatol. 2019 Jun 13. doi: 10.1111/jmp.12429. [Epub ahead of print]

Early reversal of ketamine/dexmedetomidine chemical immobilization by atipamezole in golden-headed lion tamarins (Leontopithecus chrysomelas).

Author information

1
Department of Veterinary Surgery, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil.
2
Department of Pathology, Laboratory of Wildlife Compared Pathology, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil.
3
Graduate Program for Tropical Biodiversity, Federal University of Espírito Santo, São Mateus, Brazil.
4
Pri-Matas for Biodiversity Conservation Institute, Belo Horizonte, Brazil.
5
Institutional Program for Biodiversity and Health Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.

Abstract

BACKGROUND:

A smooth and rapid recovery from anesthesia allowing safe release is desirable, especially for wild species. This study describes the clinical effects of the combination of dexmedetomidine and ketamine and the partial reversal with atipamezole in golden-headed lion tamarins.

METHODS:

Dexmedetomidine 10 μg kg-1 and ketamine 15 mg kg-1 were administered to 45 golden-headed lion tamarins undergoing vasectomy. Following surgery, animals were assigned to three groups: control (SAL; 0.9% NaCl), atipamezole 20 μg kg-1 (ATI20), and atipamezole 40 μg kg-1 (ATI40).

RESULTS AND CONCLUSIONS:

All animals presented great scores of sedation and muscle relaxation during the procedure. Recovery in the control group was smooth and uneventful. Salivation, muscle tremors, and head movements were observed in ATI 20 and ATI40. The administration of atipamezole did not change total recovery times (ATI20 69 ± 23 minutes; ATI40 72 ± 45 minutes; SAL 57 ± 23 minutes).

KEYWORDS:

anesthesia; new world primates; primates; recovery; α-2 agonist

PMID:
31194266
DOI:
10.1111/jmp.12429

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