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J Bone Jt Infect. 2019 Apr 20;4(3):115-119. doi: 10.7150/jbji.34679. eCollection 2019.

Marjolin's Tumor Complicating Chronic Periprosthetic Infection of a Total Knee Arthroplasty.

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Philadelphia College of Osteopathic Medicine Orthopaedic Surgery, Philadelphia, PA.
MedStar Georgetown Cancer Institute, National Center for Bone and Soft Tissue Tumors, MedStar Franklin Square Medical Center.
Rubin Institute for Advanced Orthopaedics, Baltimore, MD.


Marjolin's tumor is a term used to describe a malignancy developing in the setting of a chronic wound, infection, or other tissue subject to chronic inflammatory changes. These malignancies usually present after many years of chronicity, and can range from lower grade basal cell carcinomas to high-grade sarcomas. We present the case of a squamous cell carcinoma that developed within a chronic periprosthetic infection of a total knee arthroplasty of 7 years duration. The intra-articular location, association with an orthopaedic implant, and brief latency period are all unique features of this case.

Conflict of interest statement

Competing Interests: The authors have declared that no competing interest exists.

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