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Front Endocrinol (Lausanne). 2019 May 22;10:323. doi: 10.3389/fendo.2019.00323. eCollection 2019.

Preconceptional, Gestational, and Lactational Exposure to an Unconventional Oil and Gas Chemical Mixture Alters Energy Expenditure in Adult Female Mice.

Author information

1
Department of Obstetrics, Gynecology and Women's Health, University of Missouri, Columbia, MO, United States.
2
Department of Biological Sciences, University of Missouri, Columbia, MO, United States.
3
Nicholas School of the Environment, Duke University, Durham, NC, United States.
4
Department of Nutrition and Health Exercise Physiology, University of Missouri, Columbia, MO, United States.
5
Medicine-Division of Gastroenterology and Hepatology, University of Missouri, Columbia, MO, United States.
6
Research Service, Harry S Truman Memorial Veterans Medical Center, Columbia, MO, United States.
7
Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS, United States.
8
Kansas City VA Medical Center, Research Service, Kansas City, MO, United States.

Abstract

Previous studies conducted in our laboratory have found altered adult health outcomes in animals with prenatal exposure to environmentally relevant levels of unconventional oil and gas (UOG) chemicals with endocrine-disrupting activity. This study aimed to examine potential metabolic health outcomes following a preconception, prenatal and postnatal exposure to a mixture of 23 UOG chemicals. Prior to mating and from gestation day 1 to postnatal day 21, C57BL/6J mice were developmentally exposed to a laboratory-created mixture of 23 UOG chemicals in maternal drinking water. Body composition, spontaneous activity, energy expenditure, and glucose tolerance were evaluated in 7-month-old female offspring. Neither body weight nor body composition differed in 7-month female mice. However, females exposed to 1.5 and 150 μg/kg/day UOG mix had lower total and resting energy expenditure within the dark cycle. In the light cycle, the 1,500 μg//kg/day group had lower total energy expenditure and the 1.5 μg/kg/day group had lower resting energy expenditure. Females exposed to the 150 μg/kg/day group had lower spontaneous activity in the dark cycle, and females exposed to the 1,500 μg/kg/day group had lower activity in the light cycle. This study reports for the first time that developmental exposure to a mixture of 23 UOG chemicals alters energy expenditure and spontaneous activity in adult female mice.

KEYWORDS:

developmental origins of health and disease; endocrine disrupting chemicals; energy expenditure; hydraulic fracturing; metabolic disruptors; metabolism; unconventional oil and gas

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