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J Cell Biol. 2019 Jul 1;218(7):2082-2083. doi: 10.1083/jcb.201906022. Epub 2019 Jun 12.

The enemy of my enemy: PTEN and PLCXD collude to fight endosomal PtdIns(4,5)P2.

Author information

1
Department of Biology, Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, MA.
2
Department of Biology, Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, MA arodal@brandeis.edu.

Abstract

Loss of the phosphoinositide 5-phosphatase OCRL causes accumulation of PtdIns(4,5)P2 on membranes and, ultimately, Lowe syndrome. In this issue, Mondin et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201805155) discover that a surprising partnership between PTEN and the phospholipase PLCXD can compensate for OCRL to suppress endosomal PtdIns(4,5)P2 accumulation.

PMID:
31189610
PMCID:
PMC6605809
[Available on 2020-01-01]
DOI:
10.1083/jcb.201906022
[Indexed for MEDLINE]

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