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Oncol Lett. 2019 Jun;17(6):5147-5153. doi: 10.3892/ol.2019.10167. Epub 2019 Mar 19.

Differential expression of EphA5 protein in gastric carcinoma and its clinical significance.

Author information

1
Department of Pathology, Taixing People's Hospital, Taixing, Jiangsu 225400, P.R. China.
2
Department of Pathology, Nanjing Medical University, Nanjing, Jiangsu 211166, P.R. China.
3
Department of Pathology, Jinling Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu 210002, P.R. China.
4
Center of Pathology and Clinical Laboratory, Sir Run Run Hospital, Nanjing Medical University, Nanjing, Jiangsu 211166, P.R. China.

Abstract

The aim of the present study was to evaluate ephrin type-A receptor 5 (EphA5) expression and its clinicopathological significance in gastric cancer. Gastric cancer tissues were analyzed by immunohistochemistry. The association between EphA5 expression and clinicopathological parameters, human epidermal growth factor receptor 2 (HER2) status and Ki-67 proliferation index was statistically analyzed. EphA5 expression was detected in all non-tumor gastric epithelia but was differentially expressed among gastric cancer samples. EphA5 was negatively expressed in 30/110 (27.3%) and positively expressed in 80/110 (72.3%) samples from patients with gastric cancer. EphA5 expression was significantly associated with Lauren classification (P=0.032), lymph node metastasis (P<0.001), HER2 expression (P=0.020) and Ki-67 expression (P=0.005). No significant association was determined between EphA5 expression and age, sex, primary location, depth of invasion and Tumor-Node-Metastasis stage. The present data indicated that EphA5 is differentially expressed in gastric cancer. EphA5 may therefore be a potential therapeutic target and may have clinical utility as a marker for lymph node metastasis in gastric cancer.

KEYWORDS:

Ki-67; ephrin type-A receptor 5; gastric cancer; human epidermal growth factor receptor 2

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