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Sci Rep. 2019 Jun 11;9(1):8483. doi: 10.1038/s41598-019-44968-9.

Leukocyte telomere length, lipid parameters and gestational diabetes risk: a case-control study in a Chinese population.

Weng Q1,2,3, Deng K4, Wu F4, Gan M4, Li J1,3, Dai Y1,2,3, Jiang Y4, Chen J4, Dai J4, Ma H4, Hu Z4,5, Shen H4,5, Du J6,7, Hu Y8,9,10, Jin G11,12.

Author information

1
Drum Tower Clinical Medical College, Nanjing Medical University, Nanjing, 210008, China.
2
Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical School, Nanjing, 210008, China.
3
Department of Obstetrics and Gynecology, Nanjing Drum Tower Hospital, Affiliated to Nanjing University Medical School, Nanjing, 210008, China.
4
Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.
5
State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, 211166, China.
6
Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, 211166, China. dujiangbo@njmu.edu.cn.
7
State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, 211166, China. dujiangbo@njmu.edu.cn.
8
Drum Tower Clinical Medical College, Nanjing Medical University, Nanjing, 210008, China. glyyhuyali@163.com.
9
Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical School, Nanjing, 210008, China. glyyhuyali@163.com.
10
Department of Obstetrics and Gynecology, Nanjing Drum Tower Hospital, Affiliated to Nanjing University Medical School, Nanjing, 210008, China. glyyhuyali@163.com.
11
Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, 211166, China. guangfujin@njmu.edu.cn.
12
State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, 211166, China. guangfujin@njmu.edu.cn.

Abstract

Telomere length (TL) is linked to various age-related diseases, but little is known about telomeres in gestational diabetes mellitus (GDM). We surveyed 509 subjects (113 GDM patients and 396 frequency matched controls) in Nanjing Drum Tower Hospital, Jiangsu province of eastern China. Relative telomere length (RTL) of genomic DNA extracted from peripheral blood leukocytes was measured using quantitative polymerase chain reaction (qPCR). Odds ratios (OR) and 95% confidence interval (CI) of GDM risk were calculated across tertiles of RTL using logistic regression model. Lipid parameters during the third trimesters of gestation (after 32 weeks) were collected from medical records. The general linear correlation test was used to explore the associations of lipid parameters with RTL. Our results showed that the RTL in GDM patients were significantly shorter than controls (0.302 ± 0.112 vs. 0.336 ± 0.164, P = 0.046). However, the GDM risk was significantly increased in subjects with median RTL (adjusted OR [aOR]: 1.936, 95% CI: 1.086, 3.453, P = 0.025) and the shortest RTL (aOR: 1.795, 95% CI: 1.004, 3.207, P = 0.048), compared to subjects with longest RTL. We also demonstrated that the lipid ratios (TC/TG, LDL/TG, HDL/TG, LDL/TC, TC/LDL) were significantly associated with RTL among controls. Overall, the present study indicated that attrition of telomeres would increase GDM risk among pregnant women, and the altered lipid levels may play an important role in RTL related GDM risk and pathogenesis.

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