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BMC Cancer. 2019 Jun 11;19(1):567. doi: 10.1186/s12885-019-5763-5.

Long term response on Regorafenib in non-V600E BRAF mutated colon cancer: a case report.

Author information

1
Department of Gastroenterology, University Hospital Ghent, C Heymanslaan 10, 9000, Ghent, Belgium. Eduardcallebout@hotmail.com.
2
Department of Gastroenterology, University Hospital Ghent, C Heymanslaan 10, 9000, Ghent, Belgium.
3
Department of Pathology, University Hospital Ghent, C Heymanslaan 10, 9000, Ghent, Belgium.
4
Centre for Medical Genetics, University Hospital Ghent, C Heymanslaan 10, 9000, Ghent, Belgium.
5
Molecular Diagnostics, University Hospital Ghent, C Heymanslaan 10, 9000, Ghent, Belgium.

Abstract

BACKGROUND:

Non-V600E BRAF mutated colorectal cancer (CRC) is a rare disease entity with specific clinical features. These tumors are less likely to have microsatellite instability than CRC with a V600E BRAF mutation and often harbor a KRAS or NRAS mutation. Notably, median overall survival is longer than in wild-type BRAF CRC. Little is known about treatment possibilities in these patients.

CASE PRESENTATION:

We present the case of a 59 year old patient with a rare mutation in BRAF codon 594, who progressed rapidly on all classical therapies but experienced a clear and long lasting response on treatment with Regorafenib.

CONCLUSION:

Little is known about therapies that can be effective in the rare non-V600E BRAF mutated CRCs. We present a patient who had a definite response to treatment with Regorafenib. There are no predictive markers that define a subset of CRC patients who benefit most from Regorafenib. The specific features of this non-V600E BRAF mutated CRC may be relevant in the exploration of predictive biomarkers for the efficacy of Regorafenib.

KEYWORDS:

Case report; Colon cancer; Epithelial to mesenchymal transition; Non-V600E BRAF mutation; Regorafenib

PMID:
31185985
PMCID:
PMC6560823
DOI:
10.1186/s12885-019-5763-5
[Indexed for MEDLINE]
Free PMC Article

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