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Antioxidants (Basel). 2019 Jun 10;8(6). pii: E169. doi: 10.3390/antiox8060169.

Role of Cytosolic 2-Cys Prx1 and Prx2 in Redox Signaling.

Author information

1
Department of Health Sciences and Technology, Graduate School of Medicine, Gachon University, Incheon 21999, Korea. youandkys@naver.com.
2
Department of Health Sciences and Technology, Graduate School of Medicine, Gachon University, Incheon 21999, Korea. hhjang@gachon.ac.kr.
3
Department of Biochemistry, College of Medicine, Gachon University, Incheon 21999, Korea. hhjang@gachon.ac.kr.

Abstract

Peroxiredoxins (Prxs), a family of peroxidases, are reactive oxygen species scavengers that hydrolyze H2O2 through catalytic cysteine. Mammalian Prxs comprise six isoforms (typical 2-Cys Prxs; Prx1-4, atypical 2-Cys Prx; Prx5, and 1-Cys Prx; Prx6) that are distributed over various cellular compartments as they are classified according to the position and number of conserved cysteine. 2-Cys Prx1 and Prx2 are abundant proteins that are ubiquitously expressed mainly in the cytosol, and over 90% of their amino acid sequences are homologous. Prx1 and Prx2 protect cells from ROS-mediated oxidative stress through the elimination of H2O2 and regulate cellular signaling through redox-dependent mechanism. In addition, Prx1 and Prx2 are able to bind to a diversity of interaction partners to regulate other various cellular processes in cancer (i.e., regulation of the protein redox status, cell growth, apoptosis, and tumorigenesis). Thus, Prx1 and Prx2 can be potential therapeutic targets and it is particularly important to control their level or activity. This review focuses on cytosolic 2-Cys Prx1 and Prx2 and their role in the regulation of redox signaling based on protein-protein interaction.

KEYWORDS:

antioxidant enzymes; chaperone activity; hyperoxidation; peroxidase activity; peroxiredoxin; protein-protein interaction; reactive oxygen species

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