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J Agric Food Chem. 2019 Jun 11. doi: 10.1021/acs.jafc.9b02110. [Epub ahead of print]

A low ω-6/ω-3 ratio high-fat diet improves rat metabolism via purine and tryptophan metabolism in intestine tract while reversed by inulin.

Abstract

BACKGROUND:

High-fat diet (HFD) is the main cause of metabolic diseases. However, HFD in previous studies consists of much lard, which contains a large amount of omega-6 (ω-6) polyunsaturated fatty acid (PUFA) and low omega-3 (ω-3) PUFA. The role of ω-6/ω-3 ratio of HFD in the development of metabolic diseases remains incompletely discussed.

METHODS:

Rats were fed with either a low or a high ω-6/ω-3 ratio HFD singly or combined with inulin. Metabolism state was valued and metabolomics of cecal content were detected.

RESULTS:

HFD with low ω-6/ω-3 ratio promotes the glucose utilization in rats. However, inulin had different effects on metabolism with different diet. Xanthosine and kynurenic acid in cecum were positively related to epididymal white adipose tissues (eWAT) mass.

CONCLUSIONS:

The present study indicated the beneficial effects of LRD on rat metabolic state. Moreover, xanthosine and kynurenic acid were closely related to the development of metabolic diseases.

PMID:
31184122
DOI:
10.1021/acs.jafc.9b02110

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