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Cureus. 2019 Mar 25;11(3):e4318. doi: 10.7759/cureus.4318.

Cerebral Cavernous Angioma Associated with Klippel Trenaunay Syndrome Treated with Gamma Knife Radiosurgery: Case Report and Literature Review.

Author information

1
Neurosurgery, Neurospinal and Cancer Care Institute, Karachi, PAK.
2
Neurosurgery, Jinnah Postgraduate Medical Center, Karachi, PAK.
3
Neurosurgery, Jinnah Postgraduate Medical Centre, Karachi, PAK.
4
Internal Medicine, Jinnah Postgraduate Medical Centre, Karachi, PAK.

Abstract

Klippel Trenaunay syndrome (KTS) is a rare, sporadic congenital syndrome characterized by cutaneous hemangiomas, venous varicosities, and osseous-soft tissue hypertrophy of the affected limb. It is genetically heterogeneous, and its clinical presentation is variable. We report the case of a 13-year-old male with KTS, who presented with a cerebral cavernous angioma in the corpus callosum. To the best of our knowledge, this is the first reported case of its kind from Pakistan and the only known case in the literature of KTS to be treated with stereotactic radiosurgery. The possibilities of shared genetic pathways between KTS and cavernous angiomas and the need for neurovascular scrutiny in patients with this syndrome are discussed.

KEYWORDS:

cerebral cavernous angioma; gamma knife; klippel-trenaunay syndrome; krit1; kts; rap1a; rasa1; stereotactic gama knife radiosurgery

Conflict of interest statement

The authors have declared that no competing interests exist.

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