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Antimicrob Agents Chemother. 2019 Jul 25;63(8). pii: e00665-19. doi: 10.1128/AAC.00665-19. Print 2019 Aug.

In Vitro Activity of Bedaquiline and Delamanid against Nontuberculous Mycobacteria, Including Macrolide-Resistant Clinical Isolates.

Author information

1
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
2
Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
3
Department of Microbiology, Yonsei University College of Medicine, Seoul, South Korea.
4
Institute for Immunology and Immunological Disease, Yonsei University College of Medicine, Seoul, South Korea.
5
Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, South Korea.
6
Division of Mycobacterial and Respiratory Infections, National Jewish Health, Denver, Colorado, USA.
7
Department of Medicine, University of Colorado, Aurora, Colorado, USA.
8
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea wjkoh@skku.edu.
#
Contributed equally

Abstract

We evaluated the in vitro activities of the antimicrobial drugs bedaquiline and delamanid against the major pathogenic nontuberculous mycobacteria (NTM). Delamanid showed high MIC values for all NTM except Mycobacterium kansasii However, bedaquiline showed low MIC values for the major pathogenic NTM, including Mycobacterium avium complex, Mycobacterium abscessus subsp. abscessus, M. abscessus subsp. massiliense, and M. kansasii Bedaquiline also had low MIC values with macrolide-resistant NTM strains and warrants further investigation as a potential antibiotic for NTM treatment.

KEYWORDS:

Mycobacterium abscessus; Mycobacterium avium complex; Mycobacterium kansasii; bedaquiline; delamanid; nontuberculous mycobacteria

PMID:
31182533
PMCID:
PMC6658790
[Available on 2020-01-25]
DOI:
10.1128/AAC.00665-19

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