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Curr Res Transl Med. 2019 Aug;67(3):79-88. doi: 10.1016/j.retram.2019.05.002. Epub 2019 Jun 8.

An international survey on the management of patients receiving CAR T-cell therapy for haematological malignancies on behalf of the Chronic Malignancies Working Party of EBMT.

Author information

1
Dept. of Haematology, Trinity College Dublin, St. James's Hospital, Dublin 8, Ireland. Electronic address: phayden@stjames.ie.
2
EBMT Data Office, 2300 Leiden, the Netherlands.
3
Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
4
CHU de Lille, LIRIC, INSERM U995, Université de Lille, 59000, Lille, France.

Abstract

PURPOSE OF THE STUDY:

Two chimeric antigen receptor (CAR) T-cell therapies - Tisagenlecleucel (Kymriah) and Axicabtagene ciloleucel (Yescarta) - have been approved for commercial use. In order to inform forthcoming EBMT guidelines on the management of adults and children undergoing autologous CAR T-cell therapy, we undertook a survey of experienced clinicians.

METHODS:

An online survey with a dual focus on (1) 'real world' patient eligibility criteria and (2) models of care for patient follow-up was sent to experienced physicians.

RESULTS:

There were 41 respondents (10 countries) and 93% worked in FACT-JACIE-accredited transplant centres. Most felt that a history of malignancy (57%), prior allo-HCT for B-NHL (78%-81%) and prior treatment with anti-CD19/CD3 BiTE antibodies (76%-86%) do not constitute contra-indications to CAR T therapy. Clinicians were divided as to whether CNS involvement represented an exclusion criterion. There was agreement that patients with viral infections (HIV, Hepatitis B or Hepatitis C) are not eligible. There is no common model of care for long-term follow-up. Most respondents believed that patients should attend the hospital two (43%) to three (33%) times weekly during the first month following discharge. A majority (69%) of respondents work in centres where there is an MDT meeting with a specific focus on follow-up following CAR T Therapy. Follow-up care is currently delivered either in HCT or haematology-oncology outpatient clinics.

CONCLUSION:

The responses reveal wide variation in perceived patient eligibility criteria and highlight the need for consensus guidelines. The findings also illustrate the embryonic nature of current follow-up arrangements.

KEYWORDS:

CAR T; CAR T-cells; Long-term follow-up; Patient eligibility; Patient selection

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