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Rev Neurol (Paris). 2019 Jun 7. pii: S0035-3787(18)30968-8. doi: 10.1016/j.neurol.2019.03.005. [Epub ahead of print]

Arterial ischemic stroke in non-neonate children: Diagnostic and therapeutic specificities.

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French Center for Pediatric Stroke, France; Pediatric neurology, AP-HP, university hospital Necker-Enfants-malades, INSERM U894, 75015 Paris, France. Electronic address:
French Center for Pediatric Stroke, France; INSERM, Lyon university, U1059 Sainbiose, 42000 Saint-Étienne, France; CHU de Saint-Étienne, service de médecine physique et de réadaptation pédiatrique, INSERM CIC1408, 42000 Saint-Étienne, France.
French Center for Pediatric Stroke, France.
French Center for Pediatric Stroke, France; Pediatric neurology, CHU de Lille, 59000 Lille, France.
French Center for Pediatric Stroke, France; CHU d'Angers, department of physical and rehabilitation medicine, university of Angers, 49000 Angers, France.


Pediatric arterial ischemic stroke (AIS) is a severe condition, with long-lasting devastating consequences on motor and cognitive abilities, academic and social inclusion, and global life projects. Awareness about initial symptoms, implementation of pediatric stroke code protocols using MRI first and only and adapted management in the acute phase, individually tailored recanalization treatment strategies, and multidisciplinary rehabilitation programs with specific goal-centered actions are the key elements to improve pediatric AIS management and outcomes. The main cause of pediatric AIS is focal cerebral arteriopathy, a condition with unilateral focal stenosis and time-limited course requiring specific management. Sickle cell disease and moyamoya angiopathy patients need adapted screening and therapeutics.


Children; Focal cerebral arteriopathy; Rehabilitation; Stroke; Stroke code; Thrombolysis

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